ArticleNeuroscience2010
A plasma membrane Ca2+ ATPase isoform at the postsynaptic density.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Larval exposure to sertraline induces dose- and time-dependent remodeling of neuronal alternative splicing in adult Drosophila melanogaster.Molecular biology reports · 2026Article
- Targeting Plasma Membrane CaCancers · 2026Review
- Postsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuroplastin in human cognition: review of literature and future perspectives.Translational psychiatry · 2021Review
- Evidence for a role of plasma membrane calcium pumps in neurodegenerative disease: Recent developments.Neuroscience letters · 2018Review
- A Glutamatergic Spine Model to Enable Multi-Scale Modeling of Nonlinear Calcium Dynamics.Frontiers in computational neuroscience · 2018Article
- Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration.Scientific reports · 2017Article
- Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model.Frontiers in neuroscience · 2017Article
- Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Computational reconstitution of spine calcium transients from individual proteins.Frontiers in synaptic neuroscience · 2015Article
- The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.PloS one · 2013Article
- Decreases in plasma membrane Ca²⁺-ATPase in brain synaptic membrane rafts from aged rats.Journal of neurochemistry · 2012Article
- NMDA receptor-dependent afterdepolarizations are curtailed by carbonic anhydrase 14: regulation of a short-term postsynaptic potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.Molecular and cellular neurosciences · 2012Article
- The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.The European journal of neuroscience · 2012Article
- Ultrastructure of synapses in the mammalian brain.Cold Spring Harbor perspectives in biology · 2012Review
- Calcium signaling in dendritic spines.Cold Spring Harbor perspectives in biology · 2012Article
- Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.Cell calcium · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Most excitatory input in the hippocampus impinges on dendritic spines. Entry of Ca(2+) into spines through NMDA receptors can trigger a sequence of biochemical reactions leading to sustained changes in synaptic efficacy. To provide specificity, dendritic spines restrict the diffusion of Ca(2+) signaling and downstream molecules. The postsynaptic density (PSD) (the most prominent subdomain within the spine) is the site of Ca(2+) entry through NMDA receptors. We here demonstrate that Ca(2+) can also be removed via pumps embedded in the PSD. Using light- and electron-microscopic immunohistochemistry, we find that PMCA2w, a member of the plasma membrane Ca(2+)-ATPase (PMCA) family, concentrates at the PSD of most hippocampal spines. We propose that PMCA2w may be recruited into supramolecular complexes at the postsynaptic density, thus helping to regulate Ca(2+) nanodomains at subsynaptic sites. Taken together, these results suggest a novel function for PMCAs as modulators of Ca(2+) signaling at the synapse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.