ArticleBMC developmental biology2010
Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos.
Article in BMC developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Article
- Article
- Probing the impact of temperature on molecular events in a developmental system.Scientific reports · 2015Article
- Fundamental origins and limits for scaling a maternal morphogen gradient.Nature communications · 2015Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo.PloS one · 2013Article
- The importance of geometry in mathematical models of developing systems.Current opinion in genetics & development · 2012Review
- The role of Bicoid cooperative binding in the patterning of sharp borders in Drosophila melanogaster.Developmental biology · 2012Article
- BMP signaling in wing development: A critical perspective on quantitative image analysis.FEBS letters · 2012Review
- Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts.Bioinformatics (Oxford, England) · 2012Article
- Transcriptional activators and activation mechanisms.Protein & cell · 2011Review
- Scaling of the Bicoid morphogen gradient by a volume-dependent production rate.Development (Cambridge, England) · 2011Article
- A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos.PloS one · 2011Article
- Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.Nature cell biology · 2011Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatterning along the anterior-posterior (A-P) axis in Drosophila embryos is instructed by the morphogen gradient of Bicoid (Bcd). Despite extensive studies of this morphogen, how embryo geometry may affect gradient formation and target responses has not been investigated experimentally.
resultsIn this report, we systematically compare the Bcd gradient profiles and its target expression patterns on the dorsal and ventral sides of the embryo. Our results support a hypothesis that proper distance measurement and the encoded positional information of the Bcd gradient are along the perimeter of the embryo. Our results also reveal that the dorsal and ventral sides of the embryo have a fundamentally similar relationship between Bcd and its target Hunchback (Hb), suggesting that Hb expression properties on the two sides of the embryo can be directly traced to Bcd gradient properties. Our 3-D simulation studies show that a curvature difference between the two sides of an embryo is sufficient to generate Bcd gradient properties that are consistent with experimental observations.
conclusionsThe findings described in this report provide a first quantitative, experimental evaluation of embryo geometry on Bcd gradient formation and target responses. They demonstrate that the physical features of an embryo, such as its shape, are integral to how pattern is formed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.