ArticleWorld journal of gastroenterology2010
Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer.PloS one · 2019Trial
- Early-Onset Colorectal Cancer-A Retrospective Study from a Tertiary Referral Hospital in Romania.Diagnostics (Basel, Switzerland) · 2024Article
- Distinct Molecular Profiles of Sporadic Early-Onset Colorectal Cancer: A Population-Based Cohort and Systematic Review.Gastro hep advances · 2023Review
- Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery.Diagnostics (Basel, Switzerland) · 2022Article
- Comparative genomic signatures in young and old Chinese patients with colorectal cancer.Cancer medicine · 2021Article
- Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer.Frontiers in cellular and infection microbiology · 2021Review
- Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis.World journal of gastroenterology · 2019Review
- Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer.International journal of molecular sciences · 2019Article
- Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location.Oncotarget · 2018Article
- Does cyclin E and p57International journal of clinical and experimental pathology · 2018Article
- Findings in young adults at colonoscopy from a hospital service database audit.BMC gastroenterology · 2017Article
- NOMO-1 gene is deleted in early-onset colorectal cancer.Oncotarget · 2017Article
- Observational
- Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer.World journal of gastrointestinal oncology · 2016Review
- The association of age and race and the risk of large bowel polyps.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Classifying early-onset colorectal cancer according to tumor location: new potential subcategories to explore.American journal of cancer research · 2015Article
- Early-onset colorectal cancer: a separate subset of colorectal cancer.World journal of gastroenterology · 2014Review
- Early-onset colorectal cancer: a sporadic or inherited disease?World journal of gastroenterology · 2014Review
- Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study.Journal of natural science, biology, and medicine · 2014Article
- Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India.Molecular carcinogenesis · 2014Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI).
methodsForty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.
resultsEarly onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during follow-up showed a lack of expression of cyclin E, which could be a marker of poor prognosis. beta-catenin expression was normal in a high percentage of tumors.
conclusionEarly-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.