ReviewWorld journal of gastroenterology2010
Interleukin-21 triggers effector cell responses in the gut.
Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials.Immune network · 2024Review
- A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes.Journal of diabetes investigation · 2023Article
- Article
- The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation.Cells · 2020Review
- Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.Mediators of inflammation · 2020Article
- Paradoxical role of Breg-inducing cytokines in autoimmune diseases.Journal of translational autoimmunity · 2019Review
- Probiotic Mixture VSL#3 Alleviates Dextran Sulfate Sodium-induced Colitis in Mice by Downregulating T Follicular Helper Cells.Current medical science · 2019Article
- Chronic Rhinosinusitis with Polyps Is Characterized by Increased Mucosal and Blood Th17 Effector Cytokine Producing Cells.Frontiers in physiology · 2017Article
- IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice.Scientific reports · 2016Article
- Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.Pediatric nephrology (Berlin, Germany) · 2016Article
- [Roles of interleukin-21 and its receptor in autoimmune diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Inflammatory bowel disease-related arthritis - clinical evaluation and possible role of cytokines.Reumatologia · 2015Article
- Elevated expression of interleukin-21 and its correlation to T-cell subpopulation in patients with ulcerative colitis.Central-European journal of immunology · 2015Article
- Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.The Journal of allergy and clinical immunology · 2014Article
- Role of Th17 Cells in the Pathogenesis of Human IBD.ISRN inflammation · 2014Review
- Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases.BMC endocrine disorders · 2013Article
- Changes of the cytokine profile in inflammatory bowel diseases.World journal of gastroenterology · 2012Review
- The Emerging Role of Interleukin-21 in Transplantation.Journal of clinical & cellular immunology · 2012Article
- Interleukin 21 impairs tumor immunosurveillance of colitis-associated colorectal cancer.Oncoimmunology · 2012Article
- Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus.Arthritis research & therapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the gut of patients with Crohn's disease and patients with ulcerative colitis, the major forms of inflammatory bowel diseases (IBD) in humans, the tissue-damaging immune response is mediated by an active cross-talk between immune and non-immune cells. Accumulating evidence indicates also that cytokines produced by these cells play a major role in initiating and shaping this pathologic process. One such cytokine seems to be interleukin (IL)-21, a member of the common gamma-chain-receptor family. IL-21 is produced in excess in the inflamed intestine of patients with IBD mostly by activated CD4+ T helper cells co-expressing interferon-gamma and follicular T helper cells. Moreover, both in vitro and in vivo studies indicate that excessive IL-21 production leads to the activation of multiple signaling pathways that expand and sustain the ongoing mucosal inflammation. In this article, we review the available data supporting the pathogenic role of IL-21 in IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.