ArticleJournal of magnetic resonance imaging : JMRI2010
Diffusion-weighted MRI for monitoring tumor response to photodynamic therapy.
Article in Journal of magnetic resonance imaging : JMRI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- An Analysis of the Effects of In Vitro Photodynamic Therapy on Prostate Cancer Tissue by Histopathological Examination and Magnetic Resonance Imaging.International journal of molecular sciences · 2022Article
- The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Rectal gas-induced susceptibility artefacts on prostate diffusion-weighted MRI with epi read-out at 3.0 T: does a preparatory micro-enema improve image quality?Abdominal radiology (New York) · 2020Article
- Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response.BMC cancer · 2020Article
- Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma.PloS one · 2019Article
- Article
- Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.Academic radiology · 2016Review
- The expanding landscape of diffusion-weighted MRI in prostate cancer.Abdominal radiology (New York) · 2016Review
- Quantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy.PloS one · 2016Article
- Image-guided Interstitial Photodynamic Therapy for Squamous Cell Carcinomas: Preclinical investigation.Journal of oral and maxillofacial surgery, medicine, and pathology · 2015Article
- Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer.ACS nano · 2014Article
- Nonrigid point registration for 2D curves and 3D surfaces and its various applications.Physics in medicine and biology · 2013Article
- Biodistribution Study of Nanoparticle Encapsulated Photodynamic Therapy Drugs Using Multispectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- Animal models of extracranial pediatric solid tumors.Oncology letters · 2012Article
- Hyperspectral imaging and quantitative analysis for prostate cancer detection.Journal of biomedical optics · 2012Article
- The emerging role of diffusion-weighted MRI in prostate cancer management.Nature reviews. Urology · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeTo examine diffusion-weighted MRI (DW-MRI) for assessing the early tumor response to photodynamic therapy (PDT). MATERIALS AND
methodsSubcutaneous tumor xenografts of human prostate cancer cells (CWR22) were initiated in athymic nude mice. A second-generation photosensitizer, Pc 4, was delivered to each animal by a tail vein injection 48 h before laser illumination. A dedicated high-field (9.4 Tesla) small animal MR scanner was used to acquire diffusion-weighted MR images pre-PDT and 24 h after the treatment. DW-MRI and apparent diffusion coefficients (ADC) were analyzed for 24 treated and 5 control mice with photosensitizer only or laser light only. Tumor size, prostate specific antigen (PSA) level, and tumor histology were obtained at different time points to examine the treatment effect.
resultsTreated mice showed significant tumor size shrinkage and decrease of PSA level within 7 days after the treatment. The average ADC of the 24 treated tumors increased 24 h after PDT (P < 0.001) comparing with pre-PDT. The average ADC was 0.511 +/- 0.119 x 10(-3) mm(2)/s pre-PDT and 0.754 +/- 0.181 x 10(-3) mm(2)/s 24 h after the PDT. There is no significant difference in ADC values pre-PDT and 24 h after PDT in the control tumors (P = 0.20).
conclusionThe change of tumor ADC values measured by DW-MRI may provide a noninvasive imaging marker for monitoring tumor response to Pc 4-PDT as early as 24 h.
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