ArticleHeart and vessels2010
Circulating soluble CD40 ligand mediates the interaction between neutrophils and platelets in acute coronary syndrome.
Article in Heart and vessels, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Soluble CD40 ligand levels in acute pulmonary embolism: a prospective, randomized, controlled study.Heart and vessels · 2012Trial
- The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.Journal of cardiovascular translational research · 2021Review
- Association of acute myocardial infarction with influenza: A nationwide observational study.PloS one · 2020Observational
- The Biomarkers for Acute Myocardial Infarction and Heart Failure.BioMed research international · 2020Review
- Accumulations of von Willebrand factor within ECMO oxygenators: Potential indicator of coagulation abnormalities in critically ill patients?Artificial organs · 2019Article
- Variation of PEAR1 DNA methylation influences platelet and leukocyte function.Clinical epigenetics · 2019Article
- A new hydrophilic polysulfone hemodialysis membrane can prevent platelet-neutrophil interactions and successive neutrophil activation.The International journal of artificial organs · 2019Article
- Measuring and interpreting platelet-leukocyte aggregates.Platelets · 2018Review
- Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- NETosis in Cancer - Platelet-Neutrophil Crosstalk Promotes Tumor-Associated Pathology.Frontiers in immunology · 2016Review
- Platelet-neutrophil interactions under thromboinflammatory conditions.Cellular and molecular life sciences : CMLS · 2015Review
- Effect of Danhong Injection Combined with Naoxintong Tablets on Prognosis and Inflammatory Factor Expression in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.Acta Cardiologica Sinica · 2015Article
- Platelets: essential components of the immune system.Current trends in immunology · 2015Article
- Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2015Article
- Article
- Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L.Molecules (Basel, Switzerland) · 2013Article
- Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Intravascular ultrasound assessment of the association between spatial orientation of ruptured coronary plaques and remodeling morphology of culprit plaques in ST-elevation acute myocardial infarction.Heart and vessels · 2012Article
- Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy.Heart and vessels · 2012Article
- Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus.The Journal of infectious diseases · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following plaque rupture, activated platelet will induce subsequent inflammatory process including neutrophil recruitment. In vitro study demonstrated an interaction between neutrophils and platelets via a mechanism involving CD40-CD40 ligand. However, whether this mechanism exists in the clinical setting remains unknown. Fifty-four patients with acute myocardial infarction (AMI) and 25 with unstable angina of pain onset of < or = 24 h were enrolled consecutively. Acute myocardial infarction was diagnosed from three diagnostic criteria, i.e., anginal pain, electrocardiogram ST-T changes, and cardiac enzyme elevation. Unstable angina was diagnosed in patients without elevated cardiac enzymes. Peripheral venous blood was drawn at admission for routine blood count and soluble CD40 ligand (sCD40L) measurement. Neutrophil count was determined by an automated blood cell counter. Circulating sCD40L was measured using a standard enzyme-linked immunosorbent assay. Neutrophil count was significantly higher in AMI as compared with unstable angina (P < 0.001), whereas circulating sCD40L did not significantly differ. Despite marked elevation, no correlation was observed between neutrophil count and circulating sCD40L in AMI. Interestingly, we observed a strong and positive significant correlation between neutrophil count and circulating sCD40L level (r = 0.607, P = 0.002) in unstable angina. Circulating sCD40L is associated with neutrophil count and may mediate interaction between neutrophils and platelets in acute coronary syndrome, particularly in unstable angina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.