ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Evaluating causes of death in familial adenomatous polyposis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Endoscopic management of patients with familial adenomatous polyposis after prophylactic colectomy or restorative proctocolectomy - systematic review of the literature.Radiology and oncology · 2024Pooled it
- Colectomy and desmoid tumours in familial adenomatous polyposis: a systematic review and meta-analysis.Familial cancer · 2022Pooled it
- Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis.Familial cancer · 2019Pooled it
- Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial.Orphanet journal of rare diseases · 2013Trial
- Updates and controversies for desmoids in familial adenomatous polyposis.Familial cancer · 2025Review
- Reexamining Multisystem Desmoid Tumors Linked to Gardner's Syndrome: A Clinical Case.Case reports in gastrointestinal medicine · 2025Article
- Management of Desmoid Disease in Familial Adenomatous Polyposis.Clinics in colon and rectal surgery · 2024Review
- Assessment of circulating microRNA specific for patients with familial adenomatous polyposis.PloS one · 2021Article
- A Comprehensive Approach to the Management of Benign and Malignant Ampullary Lesions: Management in Hereditary and Sporadic Settings.Current gastroenterology reports · 2020Review
- Clinicopathological and molecular characteristics of abdominal desmoid tumors in the Chinese population: A single-center report of 15 cases.Oncology letters · 2019Article
- Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management.Journal of gastrointestinal oncology · 2019Article
- APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis.Familial cancer · 2018Article
- Risk factors for advanced duodenal and ampullary adenomatosis in familial adenomatous polyposis: a prospective, single-center study.Endoscopy international open · 2018Article
- Advanced duodenal neoplasia and carcinoma in familial adenomatous polyposis: outcomes of surgical management.Journal of gastrointestinal oncology · 2017Article
- The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study.Surgery today · 2017Article
- Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments.United European gastroenterology journal · 2017Article
- Duodenal adenoma surveillance in patients with familial adenomatous polyposis.World journal of gastrointestinal endoscopy · 2015Review
- Desmoid tumors: clinical features and outcome of an unpredictable and challenging manifestation of familial adenomatous polyposis.Familial cancer · 2015Article
- Comparison of proctocolectomy and ileal pouch-anal anastomosis to colectomy and ileorectal anastomosis in familial adenomatous polyposis.Familial cancer · 2015Article
- Gastric adenomas in familial adenomatous polyposis are common, but subtle, and have a benign course.Hereditary cancer in clinical practice · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial adenomatous polyposis is a genetic syndrome associated with an increased risk of colorectal cancer (CRC) and different extracolonic manifestations. GOALS: The goal of this study is to evaluate the frequency of death causes. MATERIAL AND
methodsCharts from 97 patients treated from 1977 to 2008 were reviewed. Retrieved data and family information allowed us to classify causes of death in those related to CCR to other malignancies or other causes.
resultsThere were analyzed data from 46 men (47.4%) and 51 women (52.6%) with an average age of 35.1 years (14 to 82). At diagnosis, 57 patients (58.7%) already had CRC-associated polyposis. There were performed 93 colectomies, one internal diversion, and one partial resection. Two patients were not operated on. Results from 19 deceased patients (19.5%) were analyzed. CRC, other tumors (desmoid tumors, lymphoma, and gastric cancer), and other causes (complication of duodenal cancer surgery, complication after ileorectal anastomosis (IRA), and coronary disease) were responsible for 12 (63.1%), four (21.1%), and three (15.8%) of all deaths, respectively. Death from CRC occurred in the context of either systemic, rectal, or pouch recurrence. Desmoid disease was the second cause of death (10.5% of all causes), leading to a fatal outcome 22% of all patients who developed DT during the study period. Upper digestive carcinomas were responsible for other two death cases.
conclusions(1) CRC is still the most prevalent cause of death; (2) even after curative resections, CRC can cause death through rectal or pouch malignization; (3) long-term survival was also strongly related to the development of extracolonic neoplasia, especially desmoid tumors and gastroduodenal carcinoma; (4) our results raise the need for local improvement in familiar screening and help us to define follow-up strategies and patient-information standards.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.