ArticlePloS one2010
A global metabolic shift is linked to Salmonella multicellular development.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
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- Is biofilm formation intrinsic to the origin of life?Environmental microbiology · 2023Article
- Weaving of bacterial cellulose by the Bcs secretion systems.FEMS microbiology reviews · 2022Review
- Differential Survivability of Two Genetically SimilarFrontiers in microbiology · 2021Article
- Clarithromycin Exerts an Antibiofilm Effect againstInfection and immunity · 2020Article
- Metabolic Activation of CsgD in the Regulation ofMicroorganisms · 2020Article
- NMR-Metabolomics Shows That BolA Is an Important Modulator ofMetabolites · 2019Article
- Salmonella and Reactive Oxygen Species: A Love-Hate Relationship.Journal of innate immunity · 2019Review
- Identification of a Small Molecule Anti-biofilm Agent AgainstFrontiers in microbiology · 2018Article
- The Production of Curli Amyloid Fibers Is Deeply Integrated into the Biology of Escherichia coli.Biomolecules · 2017Article
- Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling.BMC genomics · 2017Article
- Distribution of Diverse Escherichia coli between Cattle and Pasture.Microbes and environments · 2017Article
- Nutrient Composition Promotes Switching between Pellicle and Bottom Biofilm inFrontiers in microbiology · 2017Article
- Examining the Link between Biofilm Formation and the Ability of PathogenicFrontiers in veterinary science · 2017Review
- Article
- Morphological and proteomic analysis of biofilms from the Antarctic archaeon, Halorubrum lacusprofundi.Scientific reports · 2016Article
- Attachment of Salmonella strains to a plant cell wall model is modulated by surface characteristics and not by specific carbohydrate interactions.BMC microbiology · 2016Article
- Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Bacteria can elaborate complex patterns of development that are dictated by temporally ordered patterns of gene expression, typically under the control of a master regulatory pathway. For some processes, such as biofilm development, regulators that initiate the process have been identified but subsequent phenotypic changes such as stress tolerance do not seem to be under the control of these same regulators. A hallmark feature of biofilms is growth within a self-produced extracellular matrix. In this study we used metabolomics to compare Salmonella cells in rdar colony biofilms to isogenic csgD deletion mutants that do not produce an extracellular matrix. The two populations show distinct metabolite profiles. Even though CsgD controls only extracellular matrix production, metabolite signatures associated with cellular adaptations associated with stress tolerances were present in the wild type but not the mutant cells. To further explore these differences we examine the temporal gene expression of genes implicated in biofilm development and stress adaptations. In wild type cells, genes involved in a metabolic shift to gluconeogenesis and various stress-resistance pathways exhibited an ordered expression profile timed with multicellular development even though they are not CsgD regulated. In csgD mutant cells, the ordered expression was lost. We conclude that the induction of these pathways results from production of, and growth within, a self produced matrix rather than elaboration of a defined genetic program. These results predict that common physiological properties of biofilms are induced independently of regulatory pathways that initiate biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.