ArticleJournal of Korean medical science2010
Identification of novel methylation markers in hepatocellular carcinoma using a methylation array.
Article in Journal of Korean medical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential.Biochimica et biophysica acta. Reviews on cancer · 2024Review
- Blood biomarkers of hepatocellular carcinoma: a critical review.Frontiers in cell and developmental biology · 2024Review
- meth-SemiCancer: a cancer subtype classification framework via semi-supervised learning utilizing DNA methylation profiles.BMC bioinformatics · 2023Article
- Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes.Environmental health and preventive medicine · 2020Article
- Promoter-associated DNA methylation & expression profiling of genes (The Indian journal of medical research · 2019Article
- DNA methylation profiling identifies potentially significant epigenetically-regulated genes in glioblastoma multiforme.Oncology letters · 2019Article
- Using Illumina Infinium HumanMethylation 450K BeadChip to explore genome‑wide DNA methylation profiles in a human hepatocellular carcinoma cell line.Molecular medicine reports · 2018Article
- Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer.Oncology letters · 2018Article
- Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.World journal of gastroenterology · 2018Article
- Article
- IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma.Oncotarget · 2017Article
- Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma.Clinical epigenetics · 2016Article
- Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas.BMC medical genomics · 2015Article
- Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma.World journal of gastroenterology · 2015Article
- A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism.Molecular cancer · 2015Article
- Aberrant DNA methylation in hepatocellular carcinoma tumor suppression (Review).Oncology letters · 2014Article
- Role of ZIC1 methylation in hepatocellular carcinoma and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis.Cancer science · 2014Review
- Identification of the collagen type 1 α 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma.BMC cancer · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with promoter CpG island hypermethylation has been reported to be four times more frequent than genetic changes in human colorectal cancers. Hepatocellular carcinoma is also one of the human cancer types in which aberrant promoter CpG island hypermethylation is frequently found. However, the number of genes identified to date as hypermethylated for hepatocellular carcinoma (HCC) is fewer than that for colorectal cancer or gastric cancer, which can be attributed to fewer attempts to perform genome-wide methylation profiling for HCC. In the present study, we used bead-array technology and coupled methylation-specific PCR to identify new genes showing cancer-specific methylation in HCC. Twenty-four new genes have been identified as hypermethylated at their promoter CpG island loci in a cancer-specific manner. Of these, TNFRSF10C, HOXA9, NPY, and IRF5 were frequently hypermethylated in hepatocellular carcinoma tissue samples and their methylation was found to be closely associated with inactivation of gene expression. Further study will be required to elucidate the clinicopathological implications of these newly found DNA methylation markers in hepatocellular carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.