ReviewNature methods2010
Going deeper than microscopy: the optical imaging frontier in biology.
Review in Nature methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06800183 (Topical Application of Tartrazine for Enhanced Visualization of Subcutaneous Structures in Dermatology), which is not on this map. Cited by 620 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Application of Tartrazine for Enhanced Visualization of Subcutaneous Structures in Dermatology
Who cites it
620 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Image Quality Improvement Techniques and Assessment Adequacy in Clinical Optoacoustic Imaging: A Systematic Review.Biosensors · 2022Pooled it
- Post-translational modification-regulating biomaterials for regeneration.Bioactive materials · 2026Review
- Reimagining Dental Education: Integrating Digital Technologies for a Global, Digitally Native Generation-A Perspective.European journal of dentistry · 2026Article
- Sensing forces that shape tumours.Nature nanotechnology · 2026Article
- Imaging from Macro to Nanoscale: Multimodal Advances in Chemical and Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- Preclinical Imaging for the Translation of Innovative Nutritional Strategies: Current Applications and Future Perspectives.Journal of imaging · 2026Review
- Non-Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Topological robustness of optical skyrmions through a real-world free-space link.Science advances · 2026Article
- Submicromolar imaging of intrinsic chromophores by two-photon photothermal microscopy captures mitochondrial response to chemotherapy.Science advances · 2026Article
- Ultra-Wide-Field Noninvasive Imaging Through Scattering Media Via Physics-Guided Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pharmacokinetics and Tissue Distribution of Fluorescently Labeled Neoagarotetraose in Mice.Pharmaceutics · 2026Article
- Label-free interferometry platform for drug response profiling of bioprinted tumor organoids at single-organoid resolution.Nature protocols · 2026Review
- 150 MHz polymer resonator for optoacoustic mesoscopy based on a tapered optical fiber.Nature communications · 2026Article
- Ultrasound phase microscopy for rapid label-free super-resolution vascular imaging.Research square · 2026Article
- Experimental structural characterization of reflection matrices of scattering media.Biomedical optics express · 2026Article
- Bridging light and sound: A spironaphtopyran-rhodamine dyad with high-contrast photoswitching between fluorescence and photoacoustic signal.Photoacoustics · 2026Article
- A Novel Fluorescence-Triggered Auditory Feedback Photosensor for Precision Lymph Node Mapping.Sensors (Basel, Switzerland) · 2026Article
- Dual deconvolution in multiphoton structured illumination microscopy for deep-tissue super-resolution imaging.Nature communications · 2026Article
- Standardizing clinical trials in near-infrared fluorescence imaging: a workflow and regulatory framework proposal.Npj imaging · 2026Review
560 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical microscopy has been a fundamental tool of biological discovery for more than three centuries, but its in vivo tissue imaging ability has been restricted by light scattering to superficial investigations, even when confocal or multiphoton methods are used. Recent advances in optical and optoacoustic (photoacoustic) imaging now allow imaging at depths and resolutions unprecedented for optical methods. These abilities are increasingly important to understand the dynamic interactions of cellular processes at different systems levels, a major challenge of postgenome biology. This Review discusses promising photonic methods that have the ability to visualize cellular and subcellular components in tissues across different penetration scales. The methods are classified into microscopic, mesoscopic and macroscopic approaches, according to the tissue depth at which they operate. Key characteristics associated with different imaging implementations are described and the potential of these technologies in biological applications is discussed.
Indexed as
Identifiers
20676081What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.