ArticleThe pharmacogenomics journal2010
k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction.
Article in The pharmacogenomics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Clinical Decision Support Models to Optimize Controlled Ovarian Hyperstimulation: A Scoping Review.Clinical and translational science · 2026Review
- Advances in Artificial Intelligence (AI) Models and Generative Algorithms Represent a New Paradigm for Genomics Research.International journal of molecular sciences · 2025Review
- Transcriptome-based molecular subgroup identification and prognosis stratification in pediatric AML.Annals of hematology · 2025Article
- Gene regulatory network prediction using machine learning, deep learning, and hybrid approaches.Forestry research · 2025Article
- Machine learning algorithms for FPGA Implementation in biomedical engineering applications: A review.Heliyon · 2024Review
- Label-free macrophage phenotype classification using machine learning methods.Scientific reports · 2023Article
- Using Recurrent Neural Networks for Predicting Type-2 Diabetes from Genomic and Tabular Data.Diagnostics (Basel, Switzerland) · 2022Article
- Applying machine learning to explore the association between biological stress and near misses in emergency medicine residents.PloS one · 2022Article
- Effective data filtering is prerequisite for robust microbial association network construction.Frontiers in microbiology · 2022Article
- Artificial intelligence, machine learning, and deep learning for clinical outcome prediction.Emerging topics in life sciences · 2021Article
- Integration of transcriptomic data identifies key hallmark genes in hypertrophic cardiomyopathy.BMC cardiovascular disorders · 2021Article
- AI applications in functional genomics.Computational and structural biotechnology journal · 2021Review
- Impact of RNA-seq data analysis algorithms on gene expression estimation and downstream prediction.Scientific reports · 2020Article
- A recursive framework for predicting the time-course of drug sensitivity.Scientific reports · 2020Article
- Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response.Science advances · 2020Article
- Identification of arthropathy and myopathy of the temporomandibular syndrome by biomechanical facial features.Biomedical engineering online · 2020Article
- Article
- Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung.BMC cancer · 2019Article
- Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level.PloS one · 2019Article
- Integration of RNA-Seq data with heterogeneous microarray data for breast cancer profiling.BMC bioinformatics · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
In the clinical application of genomic data analysis and modeling, a number of factors contribute to the performance of disease classification and clinical outcome prediction. This study focuses on the k-nearest neighbor (KNN) modeling strategy and its clinical use. Although KNN is simple and clinically appealing, large performance variations were found among experienced data analysis teams in the MicroArray Quality Control Phase II (MAQC-II) project. For clinical end points and controls from breast cancer, neuroblastoma and multiple myeloma, we systematically generated 463,320 KNN models by varying feature ranking method, number of features, distance metric, number of neighbors, vote weighting and decision threshold. We identified factors that contribute to the MAQC-II project performance variation, and validated a KNN data analysis protocol using a newly generated clinical data set with 478 neuroblastoma patients. We interpreted the biological and practical significance of the derived KNN models, and compared their performance with existing clinical factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.