ArticleThe EMBO journal2010
An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Suppression of cofilin-1 promotes invasion in 3D hyaluronic acid matrices by promoting actin-based protrusions.Molecular biology of the cell · 2025Article
- Push or pull: how cytoskeletal crosstalk facilitates nuclear movement through 3D environments.Physical biology · 2022Review
- The Actin Regulators Involved in the Function and Related Diseases of Lymphocytes.Frontiers in immunology · 2022Review
- LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90Cellular and molecular life sciences : CMLS · 2021Article
- Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1.Communications biology · 2020Article
- Collagen density regulates the activity of tumor-infiltrating T cells.Journal for immunotherapy of cancer · 2019Article
- Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.Molecular and cellular biology · 2018Article
- The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development.PLoS biology · 2018Article
- Article
- Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy.Journal of the Royal Society, Interface · 2014Article
- Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.Cellular and molecular life sciences : CMLS · 2014Review
- The multiple faces of leukocyte interstitial migration.Seminars in immunopathology · 2014Review
- O-GlcNAcylation of cofilin promotes breast cancer cell invasion.The Journal of biological chemistry · 2013Article
- Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration.Immunological reviews · 2013Review
- The actin-bundling protein L-plastin supports T-cell motility and activation.Immunological reviews · 2013Review
- LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells.BMC cancer · 2013Article
- 3D arrays for high throughput assay of cell migration and electrotaxis.Cell biology international · 2013Article
- A formative evaluation of two evidence-based psychotherapies for PTSD in VA residential treatment programs.Journal of traumatic stress · 2013Article
- White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.Eukaryotic cell · 2013Article
- Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.PloS one · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells infiltrate peripheral tissues to execute immunosurveillance and effector functions. For this purpose, T cells first migrate on the two-dimensional (2D) surface of endothelial cells to undergo transendothelial migration. Then they change their mode of movement to undergo migration within the three-dimensional (3D)-extracellular matrix of the infiltrated tissue. As yet, no molecular mechanisms are known, which control migration exclusively in either 2D or 3D environments. Here, we describe a signalling module that controls T-cell chemotaxis specifically in 3D environments. In chemotaxing T cells, Ras activity is spatially restricted to the lamellipodium. There, Ras initiates activation of MEK, which in turn inhibits LIM-kinase 1 activity, thereby allowing dephosphorylation of the F-actin-remodelling protein cofilin. Interference with this MEK-cofilin module by either inhibition of MEK or by knockdown of cofilin reduces speed and directionality of chemotactic migration in 3D-extracellular matrices, but not on 2D substrates. This MEK-cofilin module may have an important function in the tissue positioning of T cells during an immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.