Evidence map›Paper›PMID 20676046›Full record

ReviewCell cycle (Georgetown, Tex.)2010

tRNA and cytochrome c in cell death and beyond.

Yide Mei, Jeongsik Yong, Aaron Stonestrom, Xiaolu Yang

Abstract readReview
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Proteomic screening of molecular targets of crocin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014
    Article
  9. Article
  10. Article
  11. Affinity-based target deconvolution of safranal.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yide MeiDepartment of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Jeongsik Yong
Aaron Stonestrom
Xiaolu Yang

Funding

Regulation of p53 function by DaxxR01CA088868 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YANG, XIAOLU · 2001 to 2012
$2.6M
REGULATION OF CASPASESR01GM060911 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI YANG, XIAOLU · 2000 to 2013
$2.5M
Dysregulation of ubiquitination in MALT lymphomasR01CA108872 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YANG, XIAOLU · 2006 to 2010
$1.2M
NCI NIH HHS CA108872NCI NIH HHS R01 CA088868NCI NIH HHS R01 CA108872NIGMS NIH HHS GM60911NIGMS NIH HHS R01 GM060911
6 · The paper itself

Abstract

Both transfer RNA (tRNA) and cytochrome c are essential to cellular function: tRNA mediates protein synthesis while cytochrome c is required for oxidative phosphorylation and apoptosis induction. tRNA has recently been implicated as a direct regulator of the well-conserved apoptotic role of cytochrome c. Interaction between these molecules could potentially coordinate biosynthesis, energy production and apoptosis. Here we review the diversity and dynamics of tRNA and how this class of non-coding RNAs may regulate the role of cytochrome c in apoptosis. We comment on unanswered questions in the cell biology of this interaction and how answers may influence our understanding of disease.

Indexed as

AnimalsCell DeathCytochromes cDiseaseHumansProtein BindingRNA, TransferCytochromes cRNA, Transfer

Identifiers

PMID20676046
PMCPMC2983467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.