ArticleCell cycle (Georgetown, Tex.)2010
Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.NPJ microgravity · 2024Review
- Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.Cancer research · 2021Article
- Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation.Lasers in medical science · 2020Review
- Protection from ionizing radiation-induced genotoxicity and apoptosis in rat bone marrow cells by HESA-A: a new herbal-marine compound.Journal of bioenergetics and biomembranes · 2019Article
- Article
- Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice.Scientific reports · 2016Article
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.Nature medicine · 2016Article
- Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies.Radiation research · 2015Review
- Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.Nature communications · 2015Article
- The effect of environmental chemicals on the tumor microenvironment.Carcinogenesis · 2015Review
- Hematopoietic stem cell injury induced by ionizing radiation.Antioxidants & redox signaling · 2014Review
- Article
- Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.Translational cancer research · 2013Article
- Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells.Mutation research · 2013Article
- Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Oncogene · 2013Review
- Article
- How cancer shapes evolution, and how evolution shapes cancer.Evolution · 2011Article
- Review
- Evolved tumor suppression: why are we so good at not getting cancer?Cancer research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Somatic evolution, which underlies tumor progression, is driven by two essential components: (1) diversification of phenotypes through heritable mutations and epigenetic changes and (2) selection for mutant clones which possess higher fitness. Exposure to ionizing radiation (IR ) is highly associated with increased risk of carcinogenesis. This link is traditionally attributed to causation of oncogenic mutations through the mutagenic effects of irradiation. On the other hand, potential effects of irradiation on altering fitness and increasing selection for mutant clones are frequently ignored. Recent studies bring the effects of irradiation on fitness and selection into focus, demonstrating that IR exposure results in stable reductions in the fitness of hematopoietic stem and progenitor cell populations. These reductions of fitness are associated with alteration of the adaptive landscape, increasing the selective advantages conferred by certain oncogenic mutations. Therefore, the link between irradiation and carcinogenesis might be more complex than traditionally appreciated: while mutagenic effects of irradiation should increase the probability of occurrence of oncogenic mutations, IR can also work as a tumor promoter, increasing the selective expansion of clones bearing mutations which become advantageous in the irradiation-altered environment, such as activated mutations in Notch1 or disrupting mutations in p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.