ArticleNucleic acids research2010
The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Highly interacting regions of the human genome are enriched with enhancers and bound by DNA repair proteins.Scientific reports · 2019Article
- Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes.Nucleic acids research · 2018Article
- How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation.Nucleic acids research · 2016Article
- GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data.BMC genomics · 2015Article
- Chromosome positioning from activity-based segregation.Nucleic acids research · 2014Article
- Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes.Nucleic acids research · 2014Article
- Chromatin and epigenetic features of long-range gene regulation.Nucleic acids research · 2013Review
- Modelling of crowded polymers elucidate effects of double-strand breaks in topological domains of bacterial chromosomes.Nucleic acids research · 2013Article
- Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data.Nature reviews. Genetics · 2013Review
- Article
- CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus.Nucleic acids research · 2012Article
- Physical tethering and volume exclusion determine higher-order genome organization in budding yeast.Genome research · 2012Article
- Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed.Future medicinal chemistry · 2012Review
- Chromatin interaction networks and higher order architectures of eukaryotic genomes.Journal of cellular biochemistry · 2011Article
- Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation.Nucleic acids research · 2010Article
- Transcriptional regulatory network shapes the genome structure of Saccharomyces cerevisiae.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Using numerical simulations, we investigate the underlying physical effects responsible for the overall organization of chromosomal territories in interphase nuclei. In particular, we address the following three questions: (i) why are chromosomal territories with relatively high transcriptional activity on average, closer to the centre of cell's nucleus than those with the lower activity? (ii) Why are actively transcribed genes usually located at the periphery of their chromosomal territories? (iii) Why are pair-wise contacts between active and inactive genes less frequent than those involving only active or only inactive genes? We show that transcription factories-mediated contacts between active genes belonging to different chromosomal territories are instrumental for all these features of nuclear organization to emerge spontaneously due to entropic effects arising when chromatin fibres are highly crowded.
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