ArticleEukaryotic cell2010
Sulfate assimilation mediates tellurite reduction and toxicity in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (Plant signaling & behavior · 2026Article
- Antimicrobial efficacy and amino acid substitutions associated with susceptibility to the tellurium compound AS101 against Haemophilus influenzae and Haemophilus parainfluenzae.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Anti-Pseudomonas aeruginosa biofilm activity of tellurium nanorods biosynthesized by cell lysate of Haloferax alexandrinus GUSF-1(KF796625).Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Effect of Selenium on the Growth and Lipid Accumulation of Yarrowia lipolytica Yeast.Biological trace element research · 2021Article
- Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications.International journal of molecular sciences · 2021Review
- Leaching of metals from end-of-life solar cells.Environmental science and pollution research international · 2019Article
- Fungal formation of selenium and tellurium nanoparticles.Applied microbiology and biotechnology · 2019Article
- Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae.Scientific reports · 2018Article
- Metal and metalloid biorecovery using fungi.Microbial biotechnology · 2017Article
- Disentangling genetic and epigenetic determinants of ultrafast adaptation.Molecular systems biology · 2016Article
- Yeast as a model system to study metabolic impact of selenium compounds.Microbial cell (Graz, Austria) · 2015Review
- Genetic basis of variations in nitrogen source utilization in four wine commercial yeast strains.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a century of research and increasing environmental and human health concerns, the mechanistic basis of the toxicity of derivatives of the metalloid tellurium, Te, in particular the oxyanion tellurite, Te(IV), remains unsolved. Here, we provide an unbiased view of the mechanisms of tellurium metabolism in the yeast Saccharomyces cerevisiae by measuring deviations in Te-related traits of a complete collection of gene knockout mutants. Reduction of Te(IV) and intracellular accumulation as metallic tellurium strongly correlated with loss of cellular fitness, suggesting that Te(IV) reduction and toxicity are causally linked. The sulfate assimilation pathway upstream of Met17, in particular, the sulfite reductase and its cofactor siroheme, was shown to be central to tellurite toxicity and its reduction to elemental tellurium. Gene knockout mutants with altered Te(IV) tolerance also showed a similar deviation in tolerance to both selenite and, interestingly, selenomethionine, suggesting that the toxicity of these agents stems from a common mechanism. We also show that Te(IV) reduction and toxicity in yeast is partially mediated via a mitochondrial respiratory mechanism that does not encompass the generation of substantial oxidative stress. The results reported here represent a robust base from which to attack the mechanistic details of Te(IV) toxicity and reduction in a eukaryotic organism.
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