ArticleThe Journal of biological chemistry2010
Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- The histone demethylase JMJ27 acts during the UV-induced modulation of H3K9me2 landscape and facilitates photodamage repair.Nature plants · 2024Article
- Epigenetic Regulation of Nucleotide Excision Repair.Frontiers in cell and developmental biology · 2022Review
- Genomics of Adaptations in Ungulates.Animals : an open access journal from MDPI · 2021Review
- A chromatin scaffold for DNA damage recognition: how histone methyltransferases prime nucleosomes for repair of ultraviolet light-induced lesions.Nucleic acids research · 2020Article
- Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila.Molecular genetics and genomics : MGG · 2019Article
- KDM4B: A Nail for Every Hammer?Genes · 2019Review
- Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.Human molecular genetics · 2018Article
- JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress.EMBO reports · 2017Article
- And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila.Scientific reports · 2017Article
- KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage.Nucleic acids research · 2017Article
- Histone demethylases in chromatin biology and beyond.EMBO reports · 2015Review
- Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway.Biology open · 2015Article
- Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock.Nucleic acids research · 2015Article
- The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites.Cell cycle (Georgetown, Tex.) · 2015Article
- Review
- KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis.Nucleic acids research · 2014Article
- Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer.British journal of cancer · 2014Article
- PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression.Oncogene · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin undergoes a variety of changes in response to UV-induced DNA damage, including histone acetylation. In human and Drosophila cells, this response is affected by mutations in the tumor suppressor p53. In this work, we report that there is a global decrease in trimethylated Lys-9 in histone H3 (H3K9me3) in salivary gland cells in wild type flies in response to UV irradiation. In contrast, flies with mutations in the Dmp53 gene have reduced basal levels of H3K9me3, which are then increased after UV irradiation. The reduction of H3K9me3 in response to DNA damage occurs preferentially in heterochromatin. Our experiments demonstrate that UV irradiation enhances the levels of Lys-9 demethylase (dKDM4B) transcript and protein in wild type flies, but not in Dmp53 mutant flies. Dmp53 binds to a DNA element in the dKdm4B gene as a response to UV irradiation. Furthermore, heterozygous mutants for the dKdm4B gene are more sensitive to UV irradiation; they are deficient in the removal of cyclobutane-pyrimidine dimers, and the decrease of H3K9me3 levels following DNA damage is not observed in dKdm4B mutant flies. We propose that in response to UV irradiation, Dmp53 enhances the expression of the dKDM4B histone demethylase, which demethylates H3K9me3 preferentially in heterochromatin regions. This mechanism appears to be essential for the proper function of the nucleotide excision repair system.
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