Evidence map›Paper›PMID 20674996›Full record

ArticleInternational journal of cardiology2011

Acidic and basic fibroblast growth factors involved in cardiac angiogenesis following infarction.

Tieqiang Zhao, Wenyuan Zhao, Yuanjian Chen, Robert A Ahokas, Yao Sun

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

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  14. The epicardium as a hub for heart regeneration.Nature reviews. Cardiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tieqiang ZhaoDivision of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Rm B324, Memphis, TN 38163, United States.
Wenyuan Zhao
Yuanjian Chen
Robert A Ahokas
Yao Sun
University of Tennessee Health Science Center · US

Funding

Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis PostinfarctionR01HL096503 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, YAO · 2010 to 2013
$1.5M
Oxidative Stress and Myocardial Remodeling Following MIR01HL077668 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, YAO · 2005 to 2008
$1.4M
NHLBI NIH HHS R01 HL077668NHLBI NIH HHS R01 HL096503NHLBI NIH HHS R01-HL77668
6 · The paper itself

Abstract

Acidic and basic fibroblast growth factors (FGF-1/FGF-2) promote angiogenesis in cancer. Angiogenesis is integral to cardiac repair following myocardial infarction (MI). The potential regulation of FGF-1/FGF-2 in cardiac angiogenesis postMI remains unexplored. Herein, we examined the temporal and spatial expression of FGF-1/FGF-2 and FGF receptors (FGFR) in the infarcted rat heart at days 1, 3, 7, and 14 postMI. FGF-1/-2 gene and protein expression, cells expressing FGF-1/-2 and FGFR expression were examined by quantitative in situ hybridization, RT-PCR; western blot, immunohistochemistry and quantitative in vitro autoradiography. Compared to the normal heart, we found that in the border zone and infarcted myocardium 1) FGF-1 gene expression was increased in the first week postMI and returned to control levels at week 2; FGF-1 protein levels were, however, largely reduced at day 1, then elevated at day 3 peaked at day 7 and declined at day 14; and cells expressing FGF-1 were primarily inflammatory cells; 2) FGF-2 gene expression was significantly elevated from day 1 to day 14; the increase in FGF-2 protein level was most evident at day 7 and cells expressing FGF-2 were primarily endothelial cells; 3) FGFR expression started to increase at day 3 and remained elevated thereafter; and 4) FGF-1/FGF-2 and FGFR expression remained unchanged in the noninfarcted myocardium. Thus, FGF-1/FGF-2 and FGFR expression are enhanced in the infarcted myocardium in the early stage after MI, which is spatially and temporally coincident with angiogenesis, suggesting that FGF-1/FGF-2 are involved in regulating cardiac angiogenesis and repair.

Indexed as

AnimalsFibroblast Growth Factor 1Fibroblast Growth Factor 2MaleMyocardial InfarctionNeovascularization, PathologicRatsRats, Sprague-DawleyFibroblast Growth Factor 1Fibroblast Growth Factor 2

Identifiers

PMID20674996
PMCPMC3061206
OpenAlexW2019331531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.