ArticleBiomaterials2010
Biomaterials derived from silk-tropoelastin protein systems.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The trial behind it
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Who cites it
52 citing papers in PubMed.
- Preparation, Characterization and Biocompatibility of a Silk Fibroin/Bamboo Nanofibrillated Cellulose Composite Hydrogel.Gels (Basel, Switzerland) · 2025Article
- Revolutionizing wild silk fibers: Ultrasound enhances structure, properties, and regenerability of protein biomaterials in ionic liquids.Ultrasonics sonochemistry · 2024Article
- Bridging Nature and Engineering: Protein-Derived Materials for Bio-Inspired Applications.Biomimetics (Basel, Switzerland) · 2024Review
- 3D-Printing of Silk Nanofibrils Reinforced Alginate for Soft Tissue Engineering.Pharmaceutics · 2023Article
- Sequence Control of the Self-Assembly of Elastin-Like Polypeptides into Hydrogels with Bespoke Viscoelastic and Structural Properties.Biomacromolecules · 2023Article
- Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency.Acta pharmaceutica Sinica. B · 2023Article
- Silk-Elastin-like Polymers for Acute Intraparenchymal Treatment of the Traumatically Injured Spinal Cord: A First Systematic Experimental Approach.Pharmaceutics · 2022Article
- Fast and reversible crosslinking of a silk elastin-like polymer.Acta biomaterialia · 2022Article
- Silk films with nanotopography and extracellular proteins enhance corneal epithelial wound healing.Scientific reports · 2021Article
- Expanding Canonical Spider Silk Properties through a DNA Combinatorial Approach.Materials (Basel, Switzerland) · 2020Article
- Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly.Advanced therapeutics · 2020Article
- Microstructure Transitions and Dry-Wet Spinnability of Silk Fibroin Protein from Waste Silk Quilt.Polymers · 2019Article
- Thermal Conductivity of Protein-Based Materials: A Review.Polymers · 2019Review
- Solvent-Free Strategy To Encapsulate Degradable, Implantable Metals in Silk Fibroin.ACS applied bio materials · 2018Article
- Exploring the Structural Transformation Mechanism of Chinese and Thailand Silk Fibroin Fibers and Formic-Acid Fabricated Silk Films.International journal of molecular sciences · 2018Article
- Stem Cell Sources and Graft Material for Vascular Tissue Engineering.Stem cell reviews and reports · 2018Review
- Microstructured Elastomer-PEG Hydrogels via Kinetic Capture of Aqueous Liquid-Liquid Phase Separation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Prevention of preterm birth: Novel interventions for the cervix.Seminars in perinatology · 2017Review
- Elastomers in vascular tissue engineering.Current opinion in biotechnology · 2016Review
- 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A structural protein blend system based on silkworm silk fibroin and recombinant human tropoelastin is described. Silk fibroin, a semicrystalline fibrous protein with beta-sheet crystals provides mechanical strength and controllable biodegradation, while tropoelastin, a noncrystallizable elastic protein provides elasticity. Differential scanning calorimetry (DSC) and temperature modulated DSC (TMDSC) indicated that silk becomes miscible with tropoelastin at different blend ratios, without macrophase separation. Fourier transform infrared spectroscopy (FTIR) revealed secondary structural changes of the blend system (beta-sheet content) before and after methanol treatment. Atomic Force Microscopy (AFM) nano-indentation demonstrated that blending silk and tropoelastin at different ratios resulted in modification of mechanical features, with resilience from approximately 68%- approximately 97%, and elastic modulus between 2 and 9 Mpa, depending on the ratio of the two polymers. Some of these values are close to those of native aortic elastin or elastin-like polypeptides. Significantly, during blending and drying silk-tropoelastin form micro- and nano-scale porous morphologies which promote human mesenchymal stem cell attachment and proliferation. These blends offer a new protein biomaterial system for cell support and tailored biomaterial properties to match mechanical needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.