ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2010
Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Depletion of melamine and cyanuric acid in serum from catfish Ictalurus punctatus and rainbow trout Onchorhynchus mykiss.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012Trial
- Review
- Hepatotoxic effects of melamine exposure from the weaning period in rats: a flow cytometric, electron microscopic, and histopathologic study.Toxicology research · 2021Article
- Ovarian Toxicity in Female Rats after Oral Administration of Melamine or Melamine and Cyanuric Acid.PloS one · 2016Article
- Use of urinary renal biomarkers to evaluate the nephrotoxic effects of melamine or cyanuric acid in non-pregnant and pregnant rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2014Article
- Melamine-cyanurate complexes and oxidative stress markers in trout kidney following melamine and cyanuric acid long-term co-exposure and withdrawal.Fish physiology and biochemistry · 2014Article
- Evaluation of renal toxicity by combination exposure to melamine and cyanuric Acid in male sprague-dawley rats.Toxicological research · 2014Article
- Depletion of melamine and cyanuric acid in kidney of catfish Ictalurus punctatus and trout Oncorhynchus mykiss.Journal of veterinary pharmacology and therapeutics · 2013Article
- Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013Article
- Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: gavage vs. feeding.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012Article
- Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Inhibition of heme peroxidases by melamine.Enzyme research · 2012Article
- A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid.Regulatory toxicology and pharmacology : RTP · 2011Article
- Bioaccumulation of melamine in catfish muscle following continuous, low-dose, oral administration.Journal of agricultural and food chemistry · 2011Article
- Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We evaluated renal melamine-cyanurate crystal spherulite formation after single and repeated ingestion of both melamine (MEL) and cyanuric acid (CYA) in catfish and trout. MEL and CYA were co-administered orally over a range of doses, 0.1-20mg/kg body weight (bw) of each compound, either once or repeatedly for 4, 14 or 28 days (d). In catfish, the No Observable Adverse Effects Levels (NOAELs) for crystal formation for single, 4d or 14 d dosing were 10, 2.5 and 0.5mg/kg bw, respectively. In trout, the respective NOAELs were 2.5, 2.5 and 0.5mg/kg bw. No renal crystals formed in catfish fed 0.1mg/kg bw of each compound for 28 d. Sequential administration of 20mg/kg bw of MEL followed by 20mg/kg bw of CYA or vise-versa, with waiting periods of 1, 3, 7, 14 or 21 d between compound dosing also induced renal crystal formation in fish. These studies show that both catfish and trout are sensitive, non-mammalian models, for renal crystal formation following MEL and CYA ingestion. Since fish generally excrete chemicals more slowly than mammals, they may provide a "worst case scenario" model for higher risk populations, such as infants or persons with compromised renal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.