Evidence map›Paper›PMID 20674464›Full record

ReviewCytokine & growth factor reviews2010

BMP signaling in vascular development and disease.

Jonathan W Lowery, Mark P de Caestecker

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. Considerations on the Development of Therapeutics in Vascular Calcification.Journal of cardiovascular development and disease · 2025
    Review
  3. Article
  4. Review
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  11. Endothelial Cell Differentiation and Hemogenic Specification.Cold Spring Harbor perspectives in medicine · 2022
    Review
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  13. Article
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  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jonathan W LoweryDepartment of Cell and Developmental Biology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Mark P de Caestecker
Vanderbilt University Medical Center · US

Funding

A mouse model of placental insufficiency with abnormal renal medullary patterningR21HD058302 · NICHD · VANDERBILT UNIVERSITY · PI DE CAESTECKER, MARK P. · 2009 to 2010
$420k
Cellular Defects in Familial Pulmonary HypertensionR21HL081167 · NHLBI · VANDERBILT UNIVERSITY · PI DE CAESTECKER, MARK P. · 2005 to 2006
$414k
NHLBI NIH HHS R21 HL081167NICHD NIH HHS R21 HD058302
6 · The paper itself

Abstract

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in vivo findings and distinct functional properties of the BMP signaling pathway in different vascular beds, have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature.

Indexed as

Signal TransductionAdultAnimalsBlood VesselsBone Morphogenetic Protein ReceptorsBone Morphogenetic ProteinsEmbryonic DevelopmentFamilial Primary Pulmonary HypertensionHomeostasisHumansHypertension, PulmonaryMiceMice, KnockoutMice, TransgenicNeovascularization, PhysiologicSmad ProteinsBone Morphogenetic Protein ReceptorsBone Morphogenetic ProteinsSmad Proteins

Identifiers

PMID20674464
PMCPMC2939258
OpenAlexW1979961462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.