ReviewCurrent opinion in immunology2010
Immune memory and aging: an infinite or finite resource?
Review in Current opinion in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Associations Between Immune Senescence and Immune Reconstitution Among People Living With HIV Undergoing Antiretroviral Therapy.Journal of immunology research · 2026Article
- Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan.Nature aging · 2025Article
- Immunosenescence and its related comorbidities in older people living with HIV.Infectious diseases & immunity · 2025Review
- Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.Nature communications · 2024Article
- Early life thymectomy induces arterial dysfunction in mice.GeroScience · 2024Article
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis.Frontiers in immunology · 2023Review
- Immunosenescence in Neurological Diseases-Is There Enough Evidence?Biomedicines · 2022Review
- Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change.Vaccines · 2022Review
- Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.Cell reports · 2022Article
- T cell regeneration after immunological injury.Nature reviews. Immunology · 2021Review
- Predictive Factors of Resistance to High-Dose Steroids Therapy in Acute Attacks of Neuromyelitis Optica Spectrum Disorder.Frontiers in neurology · 2020Article
- Construction of Thymus Organoids from Decellularized Thymus Scaffolds.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus.Experimental gerontology · 2018Review
- VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements.Frontiers in immunology · 2018Article
- Restoration of Thymus Function with Bioengineered Thymus Organoids.Current stem cell reports · 2016Article
- The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.Oncotarget · 2016Article
- Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection.Frontiers in microbiology · 2016Review
- Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.Cell reports · 2015Article
- Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective function. New knowledge of T cell repertoire maintenance over long periods of time, particularly when confronted with persistent pathogen challenge, is now enriched further by studies on whether recent immunological memory can 'overfill' and/or constrict prior memory responses. Along with studies on potentiation of memory responses by dietary/metabolic interventions and the recent advances on regulation of primary responses with aging, these findings provide a platform for new approaches to vaccination of older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.