ArticleNeurobiology of aging2012
BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- The link between sarcopenic obesity and Alzheimer's disease: a brain-derived neurotrophic factor point of view.The Journal of physiology · 2026Review
- ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's disease.GeroScience · 2025Article
- Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity.Experimental neurology · 2024Article
- Preclinical Pharmacology of CX1837, a High-Impact Ampakine with an Improved Safety Margin: Implications for Treating Alzheimer's Disease and Ischemic Stroke.Current Alzheimer research · 2024Article
- Kihito prevents corticosterone-induced brain dysfunctions in mice.Journal of traditional and complementary medicine · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.Neural regeneration research · 2021Review
- 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway.Molecular medicine reports · 2020Article
- Ampakine pretreatment enables a single brief hypoxic episode to evoke phrenic motor facilitation.Journal of neurophysiology · 2020Article
- Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice.Annals of translational medicine · 2020Article
- A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability.Neurobiology of disease · 2020Article
- Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring.The Journal of nutritional biochemistry · 2017Article
- Acupuncture Improved Neurological Recovery after Traumatic Brain Injury by Activating BDNF/TrkB Pathway.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder.Scientific reports · 2016Article
- Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Brain-derived neurotrophic factor and its clinical implications.Archives of medical science : AMS · 2015Article
- AMPA receptor potentiators: from drug design to cognitive enhancement.Current opinion in pharmacology · 2015Review
- Sex differences in cognitive impairment and Alzheimer's disease.Frontiers in neuroendocrinology · 2014Review
- Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Brain sex matters: estrogen in cognition and Alzheimer's disease.Molecular and cellular endocrinology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) has emerged as a possible broad-spectrum treatment for the plasticity losses found in rodent models of human conditions associated with memory and cognitive deficits. We have tested this strategy in the particular case of ovariectomy. The actin polymerization in spines normally found after patterned afferent stimulation was greatly reduced, along with the stabilization of long-term potentiation, in hippocampal slices prepared from middle-aged ovariectomized rats. Both effects were fully restored by a 60-minute infusion of 2 nM BDNF. Comparable rescue results were obtained after elevating endogenous BDNF protein levels in hippocampus with 4 daily injections of a short half-life ampakine (positive modulator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate [AMPA]-type glutamate receptors). These results provide the first evidence that minimally invasive, mechanism-based drug treatments can ameliorate defects in spine plasticity caused by depressed estrogen levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.