Trial reportThe Journal of clinical psychiatry2011
Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention study.
Trial report in The Journal of clinical psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Pharmacological interventions for antisocial personality disorder.The Cochrane database of systematic reviews · 2020Pooled it
- Cognitive behavioural group therapy for male perpetrators of intimate partner violence: a systematic review.BMC psychiatry · 2019Pooled it
- Alcohol interventions, alcohol policy and intimate partner violence: a systematic review.BMC public health · 2014Pooled it
- A randomized controlled trial examining the effects of intranasal oxytocin on alcohol craving and intimate partner aggression among couples.Journal of psychiatric research · 2022Trial
- Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder.Psychiatry research · 2015Trial
- Women's experiences of changes in related men's impulsivity and domestic violence following men's participation in the ReINVEST clinical trial.BMC public health · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs).Current neuropharmacology · 2022Review
- Aggressive behavior among military veterans in substance use disorder treatment: the roles of posttraumatic stress and impulsivity.Journal of substance abuse treatment · 2015Article
- [Antidepressive agents and suicidal tendencies].Der Nervenarzt · 2014Review
- The physician's unique role in preventing violence: a neglected opportunity?BMC medicine · 2012Review
- Antidepressants and lethal violence in the Netherlands 1994-2008.Psychopharmacology · 2012Article
- Evidence for biological roots in the transgenerational transmission of intimate partner violence.Translational psychiatry · 2012Article
- Cognitive and neurobiological mechanisms of alcohol-related aggression.Nature reviews. Neuroscience · 2011Review
- Biological Correlates of Intimate Partner Violence Perpetration.Aggression and violent behavior · 2010Article
- Interpersonal Coordination of Head Motion in Distressed Couples.IEEE transactions on affective computingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBehaviorally based therapies for the treatment of perpetrators who initiate intimate partner violence (IPV) have generally shown minimal therapeutic efficacy. To explore a new treatment approach for IPV, we examined the effects of a selective serotonin reuptake inhibitor on the irritability subscale score of the Modified Overt Aggression Scale. This score served as a surrogate marker for the anger and physical aggression that characterize perpetrators of IPV.
methodA 12-week, double-blind, randomized, placebo-controlled intervention study employing fluoxetine, alcohol treatment, and cognitive-behavioral therapy was performed. Sixty (46 men) non-court-mandated, DSM-IV-diagnosed alcoholic perpetrators of IPV with a history of at least 2 episodes of IPV in the year prior to participation in the study were evaluated. The primary outcome measure was the score on the irritability subscale of the Modified Overt Aggression Scale. Secondary measures included anxiety, depression, and ratings by the perpetrator's spouse/significant other. The study was conducted from January 2002 through December 2007.
resultsA repeated-measures analysis of variance using the irritability subscale scores obtained from perpetrators who completed the 12-week study (n = 24) showed a significant drug effect (F(1,21) = 12.09, P = .002). Last observation carried forward (F(1,32) = 4.24, P = .048) as well as intent-to-treat analysis (F(1,54) = 5.0, P = .034) also showed a significant drug effect. Spouses'/significant others' physical and nonphysical Partner Abuse Scale ratings showed a significant reduction of abuse over time (F(1,11) = 10.2, P = .009 and F(1,11) = 24.2, P = .0005, respectively).
conclusionThis is the first controlled study to show that a pharmacologic intervention employing a selective serotonin reuptake inhibitor, in conjunction with alcohol treatment and cognitive-behavioral therapy, can reduce measures of anger and physical aggression in alcoholic perpetrators of IPV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.