ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2010
[Expression and its clinical significance of SHP2 in non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer.OncoTargets and therapy · 2019Article
- Functions of Shp2 in cancer.Journal of cellular and molecular medicine · 2015Review
- [Expression and clinical significance of SHP2 in the tumor tissues of smokers with lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
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5 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectivePrecious studies proven that aberrant tyrosine phosphorylation has linked with cancer. The aim of this work is to study the expression and significance of SHP2 in non-small cell lung cancer (NSCLC) through tissue microarray technique and immunohistochemical method.
methodsEighty NSCLC specimens were constructed into tissue microarray and performed using immunohistochemistry.
resultsThe total positive rates of SHP2 were 70.7% (56/80) in NSCLC, 72.5% (29/40) in squamous cell carcinoma and 75% (27/40) in adenocarcinoma, which was not significant difference in sex, age, the size of tumor, histology, clinical stages and differentiation (P > 0.05), the positive rates of SHP2 were significantly higher in the cases with lymphnode metastasis than those without (P < 0.05).
conclusionThe expression rate of SHP2 is high and closely correlated to lymphnode metastasis in NSCLC, which implies the occurrence and development of lung cancer maybe related to SHP2, and SHP2 maybe a new marker and therapeutic targets for lung cancer.
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