ArticleMolecular pain2010
Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain.
Article in Molecular pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- RUNX1 Induces Central Neuropathic Pain by Activating Microglia and Triggering the Inflammatory Response in Spinal Cord Injury.Inflammation · 2025Article
- Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons.Communications biology · 2025Article
- Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain.iScience · 2022Article
- The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice.Science advances · 2022Article
- A functional subdivision within the somatosensory system and its implications for pain research.Neuron · 2022Review
- Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.Frontiers in molecular neuroscience · 2022Article
- NOCICEPTRA: Gene and microRNA Signatures and Their Trajectories Characterizing Human iPSC-Derived Nociceptor Maturation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- The development of somatosensory neurons: Insights into pain and itch.Current topics in developmental biology · 2021Review
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- Expression and localization of MrgprD in mouse intestinal tract.Cell and tissue research · 2019Article
- Identifying the pathways required for coping behaviours associated with sustained pain.Nature · 2019Article
- Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes Differentially to Environmental Enrichment Combined with Voluntary Exercise in Alleviating Chronic Inflammatory Pain in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- HDAC4 is required for inflammation-associated thermal hypersensitivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Genetic control of the segregation of pain-related sensory neurons innervating the cutaneous versus deep tissues.Cell reports · 2013Article
- The fundamental unit of pain is the cell.Pain · 2013Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron phenotypes necessary for inflammatory and neuropathic pain.
resultsHere we show that expression of Runx1-dependent ion channels and receptors is distributed into two nociceptor populations that are distinguished by persistent or transient Runx1 expression. Conditional mutation of Runx1 at perinatal stages leads to preferential impairment of Runx1-persistent nociceptors and a selective defect in inflammatory pain. Conversely, constitutive Runx1 expression in Runx1-transient nociceptors leads to an impairment of Runx1-transient nociceptors and a selective deficit in neuropathic pain. Notably, the subdivision of Runx1-persistent and Runx1-transient nociceptors does not follow the classical nociceptor subdivision into IB4+ nonpeptidergic and IB4- peptidergic populations.
conclusionAltogether, we have uncovered two distinct Runx1-dependent nociceptor differentiation programs that are permissive for inflammatory versus neuropathic pain. These studies lend support to a transcription factor-based distinction of neuronal classes necessary for inflammatory versus neuropathic pain.
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