ArticleIEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society2010
Review of Neurosurgical Fluorescence Imaging Methodologies.
Article in IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results.Acta neurochirurgica · 2017Pooled it
- Intraoperative Near-Infrared Optical Contrast Can Localize Brain Metastases.World neurosurgery · 2017Trial
- Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.Journal of neurosurgery · 2011Trial
- Label-free wide-field imaging of brain tumors using near-infrared endogenous fluorescence and reflectance normalization.Journal of biomedical optics · 2026Article
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Review
- Hyperspectral imaging in neurosurgery: a review of systems, computational methods, and clinical applications.Journal of biomedical optics · 2025Review
- Introduction to the Special Issue on Molecular Guided Surgery.Journal of biomedical optics · 2025Article
- Fluorescent probes for sensing and visualizing methylglyoxal: progress, challenges, and perspectives.RSC advances · 2024Review
- Safety, efficacy, and side effects of sodium fluorescein-aided resection of glioblastoma: a quasi-experimental study.Annals of medicine and surgery (2012) · 2024Article
- Photodynamic Therapy: Past, Current, and Future.International journal of molecular sciences · 2024Review
- Pressure-enhanced sensing of tissue oxygenation via endogenous porphyrin: Implications for dynamic visualization of cancer in surgery.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Fluorescence in neurosurgery: its therapeutic and diagnostic significance - a comprehensive review.Annals of medicine and surgery (2012) · 2024Article
- 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review.Frontiers in neuroscience · 2024Review
- Development of a glass-based imaging phantom to model the optical properties of human tissue.Biomedical optics express · 2024Article
- Assessment of open-field fluorescence guided surgery systems: implementing a standardized method for characterization and comparison.Journal of biomedical optics · 2023Article
- A birefringent spectral demultiplexer enables fast hyper-spectral imaging of protoporphyrin IX during neurosurgery.Communications biology · 2023Article
- Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements.Scientific reports · 2023Article
- Redosing of Fluorescein Sodium Improves Image Interpretation During IntraoperativeFrontiers in oncology · 2021Article
- Evaluation of multi-wavelengths LED-based photoacoustic imaging for maximum safe resection of glioma: a proof of concept study.International journal of computer assisted radiology and surgery · 2020Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Fluorescence imaging in neurosurgery has a long historical development, with several different biomarkers and biochemical agents being used, and several technological approaches. This review focuses on the different contrast agents, summarizing endogenous fluorescence, exogenously stimulated fluorescence and exogenous contrast agents, and then on tools used for imaging. It ends with a summary of key clinical trials that lead to consensus studies. The practical utility of protoporphyrin IX (PpIX) as stimulated by administration of δ-aminolevulinic acid (ALA) has had substantial pilot clinical studies and basic science research completed. Recently multi-center clinical trials using PpIx fluorescence to guide resection have shown efficacy for improved short term survival. Exogenous agents are being developed and tested pre-clinically, and hopefully hold the potential for long term survival benefit if they provide additional capabilities for resection of micro-invasive disease or certain tumor sub-types that do not produce PpIX or help delineate low grade tumors. The range of technologies used for measurement and imaging ranges widely, with most clinical trials being carried out with either point probes or modified surgical microscopes. At this point in time, optimized probe approaches are showing efficacy in clinical trials, and fully commercialized imaging systems are emerging, which will clearly help lead to adoption into neurosurgical practice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.