Evidence map›Paper›PMID 20671804›Full record

ReviewIEEE reviews in biomedical engineering2009

Histopathological image analysis: a review.

Metin N Gurcan, Laura E Boucheron, Ali Can, Anant Madabhushi, Nasir M Rajpoot, B Yener

Abstract readReview
In one paragraph

Review in IEEE reviews in biomedical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 548 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
548citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

548 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Transcription Factor TBX5 Enhances Structural Complexity and Calcium Transient Synchronization in Spontaneously Active Neonatal Rat Cardiomyocyte Cultures.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026
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488 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Metin N GurcanDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA. metin.gurcan@osumc.edu
Laura E Boucheron
Ali Can
Anant Madabhushi
Nasir M Rajpoot
B Yener

Funding

Software to facilitate multimode, multiscale fused data for Pathology and RadioloR01CA136535 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, MICHAEL D, MADABHUSHI, ANANT · 2009 to 2013
$3.2M
Computer-based assessment of tumor microenvironment (TME) in Follicular LymphomaR01CA134451 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GURCAN, METIN NAFI, LOZANSKI, GERARD · 2009 to 2017
$2.3M
OAMiner: Integrative Knowledge Anchored Hypothesis DiscoveryR01LM010119 · NLM · OHIO STATE UNIVERSITY · PI GURCAN, METIN NAFI · 2009 to 2010
$1.2M
Detecting Prostate Cancer using multi-protocol 3 Tesla in vivo MRI and MRSR21CA127186 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MADABHUSHI, ANANT · 2007 to 2009
$403k
Integrating Quantitative Histological Image and Vascular Density Patterns for ProR03CA143991 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MADABHUSHI, ANANT · 2009 to 2010
$161k
Detecting pre-cancerous lesions from high resolution prostate MRIR03CA128081 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MADABHUSHI, ANANT · 2007 to 2008
$159k
NCI NIH HHS ARRA-NCL-3 21CA127186-02S1NCI NIH HHS R01 CA134451NCI NIH HHS R01 CA136535NCI NIH HHS R01CA136535-01NCI NIH HHS R03 CA128081NCI NIH HHS R03CA128081-01NCI NIH HHS R03 CA143991NCI NIH HHS R03CA143991-01NCI NIH HHS R21 CA127186NCI NIH HHS R21CA127186-01NLM NIH HHS R01 LM010119NLM NIH HHS R01LM010119
6 · The paper itself

Abstract

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe.

Indexed as

HistocytochemistryAlgorithmsArtificial IntelligenceEuropeHumansImage Interpretation, Computer-AssistedPrognosisUnited Statescomputer-assisted interpretationhistopathologyimage analysismicroscopy analysis

Identifiers

PMID20671804
PMCPMC2910932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.