ArticleNanoscale research letters2010
Probing specific interaction forces between human IgG and rat anti-human IgG by self-assembled monolayer and atomic force microscopy.
Article in Nanoscale research letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Nanomechanical characterization of soft nanomaterial using atomic force microscopy.Materials today. Bio · 2025Review
- Investigating the Effect of Tyrosine Kinase Inhibitors on the Interaction between Human Serum Albumin by Atomic Force Microscopy.Biomolecules · 2022Article
- Probing Changes in CaMicromachines · 2020Article
- A total internal reflection ellipsometry and atomic force microscopy study of interactions between Proteus mirabilis lipopolysaccharides and antibodies.European biophysics journal : EBJ · 2015Article
- Article
- Atomic force microscopy recognition of protein A on Staphylococcus aureus cell surfaces by labelling with IgG-Au conjugates.Beilstein journal of nanotechnology · 2013Article
- Evaluating interaction forces between BSA and rabbit anti-BSA in sulphathiazole sodium, tylosin and levofloxacin solution by AFM.Nanoscale research letters · 2011Article
- Imaging and determining friction forces of specific interactions between human IgG and rat anti-human IgG.Journal of biological physics · 2011Article
- Protein crystallization facilitated by molecularly imprinted polymers.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interaction forces between biological molecules such as antigen and antibody play important roles in many biological processes, but probing these forces remains technically challenging. Here, we investigated the specific interaction and unbinding forces between human IgG and rat anti-human IgG using self assembled monolayer (SAM) method for sample preparation and atomic force microscopy (AFM) for interaction force measurement. The specific interaction force between human IgG and rat anti-human IgG was found to be 0.6-1.0 nN, and the force required for unbinding a single pair of human IgG and rat anti-human IgG was calculated to be 144 ± 11 pN. The results are consistent with those reported in the literatures. Therefore, SAM for sample preparation combined with AFM for interaction measurement is a relatively simple, sensitive and reliable technique to probe specific interactions between biological molecules such as antigen and antibody.
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