ArticleEMBO reports2010
Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions.
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Replication Stress and Consequential Instability of the Genome and Epigenome.Molecules (Basel, Switzerland) · 2019Review
- The impact of replication stress on replication dynamics and DNA damage in vertebrate cells.Nature reviews. Genetics · 2017Review
- Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress.PLoS genetics · 2016Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription.EMBO reports · 2014Article
- The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells.PLoS genetics · 2014Article
- Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.Epigenetics & chromatin · 2013Article
- Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation.Nucleic acids research · 2013Article
- USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator.PLoS biology · 2012Article
- DNA replication fading as proliferating cells advance in their commitment to terminal differentiation.Scientific reports · 2012Article
- Open sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (Igh) locus.Current opinion in cell biology · 2011Review
- Genomic approaches to the initiation of DNA replication and chromatin structure reveal a complex relationship.Briefings in functional genomics · 2011Review
- [Regulation of DNA replication timing].Molekuliarnaia biologiiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, only a fraction of replication origins fire at each S phase. Local histone acetylation was proposed to control firing efficiency of origins, but conflicting results were obtained. We report that local histone acetylation does not reflect origin efficiencies along the adenosine monophosphate deaminase 2 locus in mammalian fibroblasts. Reciprocally, modulation of origin efficiency does not affect acetylation. However, treatment with a deacetylase inhibitor changes the initiation pattern. We demonstrate that this treatment alters pyrimidine biosynthesis and decreases fork speed, which recruits latent origins. Our findings reconcile results that seemed inconsistent and reveal an unsuspected effect of deacetylase inhibitors on replication dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.