ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Hypernatremia and grade III/IV intraventricular hemorrhage among extremely low birth weight infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Higher versus lower sodium intake for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Sodium Values During the First 10 Postnatal Days in Extremely-Low-Birth-Weight Infants and Long-Term Neurocognitive Outcomes: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Hypernatremia during the first week of life in very preterm infants and neurodevelopmental outcomes at 3 to 4 years of age: a cohort study.BMC pediatrics · 2026Article
- Early glucose and sodium trajectories and short-term outcomes in extremely preterm infants.Frontiers in pediatrics · 2026Article
- Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants.JPGN reports · 2024Article
- New frontiers in neonatal red blood cell transfusion research.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Increasing Sodium Variability in the First 96 Hours after Birth is Associated with Adverse In-Hospital Outcomes of Preterm Newborns.Current developments in nutrition · 2023Article
- Neurodevelopmental consequences of early plasma sodium changes in very preterm infants.Pediatric research · 2022Article
- Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study.Children (Basel, Switzerland) · 2022Article
- Individualized fluid management in extremely preterm neonates to ensure adequate diuresis without increasing complications.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2018Article
- Sodium supply influences plasma sodium concentration and the risks of hyper- and hyponatremia in extremely preterm infants.Pediatric research · 2017Observational
- Article
- Does hyperglycemia in hypernatremic preterm infants increase the risk of intraventricular hemorrhage?Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Early sodium and fluid intake and severe intraventricular hemorrhage in extremely low birth weight infants.Journal of Korean medical science · 2015Article
- A Systematic Review and Meta-analysis of the Timing of Early Intraventricular Hemorrhage in Preterm Neonates: Clinical and Research Implications.Journal of clinical neonatology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify the risk factors contributing to intraventricular hemorrhage (IVH) in extremely low birth weight infants during early postnatal life, after appropriate matching for gestational age (GA) and birth body weight (BBW). STUDY
designA case-control retrospective study was designed to evaluate preterm infants with a GA ≤ 26 weeks and a BBW ≤ 1000 g admitted to our hospital during a 7.5-year period. From a cohort of 347 preterm infants, 36 infants (10.7%) had severe IVH (grades III and/or IV). We selected a control group of 36 preterm infants without IVH who were closely matched for GA (± 1 week) and body weight (± 100 g). Univariate and multivariate logistic regression analyses were performed to identify risk factors for severe IVH.
resultThe GA and BBW of the IVH and control groups were 24.6 ± 1 weeks and 764.4 ± 118.5 g, and 24.8 ± 0.9 weeks and 771.5 ± 125.9 g, respectively. Vaginal delivery, male sex, resuscitation in the delivery room, high sodium serum levels (meq l(-1)) (162.6 vs 148.8), fluctuation of serum sodium (meq l(-1)) (17.3 vs 6.2), pH, PaCO(2), hemoglobin and platelet counts were associated with an increased risk of severe IVH. Multivariate logistic regression indicated that sodium fluctuations >13 meq l(-1), vaginal delivery, male sex and hemoglobin fluctuations are strongly associated with the development of severe IVH.
conclusionHypernatremia and fluctuations of sodium seem to be related to early severe IVH among preterm infants; however, further studies are required to clarify the causal relationship.
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Registered trials
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