ReviewCurrent opinion in rheumatology2010
Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis.
Review in Current opinion in rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Diagnostic validity of colchicine in patients with Familial Mediterranean fever.Clinical rheumatology · 2014Trial
- Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge.Clinical reviews in allergy & immunology · 2021Review
- Familial Mediterranean fever phenotype progression into anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis:a case report.Fukushima journal of medical science · 2020Article
- Dose-dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever.Bosnian journal of basic medical sciences · 2018Article
- Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non-asthmatic Patients with Bacterial, Viral or Mixed Lung Infection.Scandinavian journal of immunology · 2017Article
- Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses.Cellular & molecular immunology · 2017Review
- Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.The Journal of allergy and clinical immunology · 2017Article
- Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever.Journal of Korean medical science · 2016Article
- Inflammation-a Critical Appreciation of the Role of Myeloid Cells.Microbiology spectrum · 2016Review
- Autoinflammation and HLA-B27: Beyond Antigen Presentation.Ocular immunology and inflammation · 2016Review
- Observational Study of a French and Belgian Multicenter Cohort of 23 Patients Diagnosed in Adulthood With Mevalonate Kinase Deficiency.Medicine · 2016Observational
- Assessing disease severity and activity in patients with familial Mediterranean fever.Inflammation · 2014Article
- Periodic Fever: A Review on Clinical, Management and Guideline for Iranian Patients - Part II.Iranian journal of pediatrics · 2014Article
- Increased cytokine/chemokines in serum from asthmatic and non-asthmatic patients with viral respiratory infection.Influenza and other respiratory viruses · 2014Article
- Monogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation.Rheumatic diseases clinics of North America · 2013Review
- Article
- The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still's disease.Rheumatology international · 2013Article
- Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.PloS one · 2013Article
- Genetics of proteasome diseases.Scientifica · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe genetic and clinical characterizations of monogenic autoinflammatory syndromes have led to ground breaking insights into the regulation of inflammatory responses to endogenous and exogenous inducers or triggers of inflammation and continue to uncover key inflammatory pathways of the innate immune system. This article summarizes recent progress in the clinical aspects and understanding of the pathogenesis of this growing spectrum of diseases. RECENT
findingsThe understanding of the spectrum of organ manifestations in autoinflammation was expanded by the discovery of two novel monogenic diseases both caused by the absence of an anti-inflammatory signal and added evidence that increased IL-1 signaling can cause aseptic osteolytic bone lesions and that the absence of IL-10 signaling causes inflammatory enterocolitis in neonates. New knock in animal models for TNF-receptor-associated periodic syndrome, and familial Mediterranean fever and cryopyrin-associated periodic syndromes allow insights into the complexity of the dysregulated immune pathways. Exploring 'triggers' of the NLRP3 inflammasome spurred studies of tissue inflammation in diseases including gout and those that previously have not been considered inflammatory in nature such as diabetes, fibrosing lung disease and possibly coronary artery disease. SUMMARY: The genetic characterization of a growing number of monogenic autoinflammatory diseases has provided important insights into the phenotypic expression of single gene disorders and the complexity of the dysregulated inflammatory pathways leading to clinical disease. Knowledge obtained from these disorders is pertinent to a number of common disorders and provides new targets for drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.