ArticleMolecular cell2010
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.
Article in Molecular cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- RTEL1 mutation modifies dyskeratosis congenita caused by a telomerase RNA template mutation.Nature communications · 2026Article
- Optimized primer and model improve precision of X chromosome telomere length determination in the Han population.iScience · 2026Article
- A persistent variant telomere sequence in a human pedigree.Nature communications · 2024Article
- The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients.Nature communications · 2024Article
- Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism.Nature communications · 2023Article
- Dynamics of TRF1 organizing a single human telomere.Nucleic acids research · 2021Article
- How RNAi machinery enters the world of telomerase.Cell cycle (Georgetown, Tex.) · 2019Review
- Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis.Nucleic acids research · 2018Article
- Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.Nature communications · 2018Article
- Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.International journal of molecular sciences · 2018Review
- Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid.The Journal of molecular diagnostics : JMD · 2018Article
- Telomere length regulation through epidermal growth factor receptor signaling in cancer.Genes & cancer · 2017Review
- Evolutionary perspectives of telomerase RNA structure and function.RNA biology · 2016Review
- Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Genome research · 2016Article
- Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.Autophagy · 2015Article
- A self-regulating template in human telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Nucleic acids research · 2014Article
- In situ visualization of telomere elongation patterns in human cells.Nucleic acids research · 2013Article
- Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development.Epigenetics & chromatin · 2013Article
- Telomere dysfunction and chromosome instability.Mutation research · 2012Review
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Authors and funding
3 authors.
Funding
Abstract
Mammalian telomeres consist of tandem DNA repeats that bind protective protein factors collectively termed shelterins. Telomere disruption typically results in genome instability induced by telomere fusions. The mechanism of telomere fusion varies depending on the means of telomere disruption. Here, we investigate telomere fusions caused by overexpression of mutant telomerases that add mutated telomeric repeats, thereby compromising shelterin binding to telomeric termini. While all mutant telomeric sequences tested induced heterodicentric chromosome fusions in ATM-competent cells, only those mutant repeat sequences with significant self complementarity induced ATM-independent sister chromatid and isodicentric chromosome fusions. Thus, once a telomere becomes dysfunctional, the terminal telomeric sequence itself determines the fate of that telomere. These results suggest that annealing of self-complementary DNA sequence engages an alternative telomere fusion pathway in human cells, and provide one explanation for the conspicuous lack of self complementarity in the majority of known naturally occurring eukaryotic telomeric sequences.
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