Evidence map›Paper›PMID 20670637›Full record

ArticlePhysiology & behavior2010

Role of melanin-concentrating hormone in the control of ethanol consumption: Region-specific effects revealed by expression and injection studies.

I Morganstern, G-Q Chang, Y-W Chen, J R Barson, Y Zhiyu, B G Hoebel, S F Leibowitz

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

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  13. Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
  14. Hypothalamic neuropeptide signaling in alcohol addiction.Progress in neuro-psychopharmacology & biological psychiatry · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

I MorgansternLaboratory of Behavioral Neurobiology, The Rockefeller University, New York, NY 10065, USA.
G-Q Chang
Y-W Chen
J R Barson
Y Zhiyu
B G Hoebel
S F Leibowitz
Rockefeller University · USPrinceton University · US

Funding

HYPOTHALAMIC PEPTIDES IN THE CONTROL OF ALCOHOL INTAKER01AA012882 · NIAAA · ROCKEFELLER UNIVERSITY · PI LEIBOWITZ, SARAH F. · 2001 to 2015
$4.0M
NIAAA NIH HHS AA12882NIAAA NIH HHS R01 AA012882
6 · The paper itself

Abstract

The peptide melanin-concentrating hormone (MCH), produced mainly by cells in the lateral hypothalamus (LH), perifornical area (PF) and zona incerta (ZI), is suggested to have a role in the consumption of rewarding substances, such as ethanol, sucrose and palatable food. However, there is limited information on the specific brain sites where MCH acts to stimulate intake of these rewarding substances and on the feedback effects that their consumption has on the expression of endogenous MCH. The current study investigated MCH in relation to ethanol consumption, in Sprague-Dawley rats. In Experiment 1, chronic consumption of ethanol (from 0.70 to 2.7 g/kg/day) dose-dependently reduced MCH gene expression in the LH. In Experiments 2-4, the opposite effect was observed with acute oral ethanol, which stimulated MCH expression specifically in the LH but not the ZI. In Experiment 5, the effect of MCH injection in brain-cannulated rats on ethanol consumption was examined. Compared to saline, MCH injected in the paraventricular nucleus (PVN) and nucleus accumbens (NAc) selectively stimulated ethanol consumption without affecting food or water intake. In contrast, it reduced ethanol intake when administered into the LH, while having no effect in the ZI. These results demonstrate that voluntary, chronic consumption of ethanol leads to local negative feedback control of MCH expression in the LH. However, with a brief exposure, ethanol stimulates MCH-expressing neurons in this region, which through projections to the feeding-related PVN and reward-related NAc can promote further drinking behavior.

Indexed as

Alcohol DrinkingAnalysis of VarianceAnimalsBrain MappingCentral Nervous System DepressantsDose-Response Relationship, DrugEthanolFeedback, PhysiologicalFornix, BrainGene Expression RegulationHypothalamic Area, LateralHypothalamic HormonesMaleMelaninsMicroinjectionsNeural PathwaysCentral Nervous System DepressantsEthanolHypothalamic Hormonesmelanin-concentrating hormoneMelaninsPituitary Hormones

Identifiers

PMID20670637
PMCPMC2949500
OpenAlexW2069790224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.