Evidence map›Paper›PMID 20670600›Full record

ReviewDiscovery medicine2010

Noroviruses: The leading cause of gastroenteritis worldwide.

Hoonmo L Koo, Nadim Ajami, Robert L Atmar, Herbert L DuPont

Abstract readReview
In one paragraph

Review in Discovery medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. The burden of norovirus disease in children in the European Union.The Pediatric infectious disease journal · 2015
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hoonmo L KooBaylor College of Medicine, Houston, Texas, USA. koo@bcm.tmc.edu
Nadim Ajami
Robert L Atmar
Herbert L DuPont

Funding

WRCE Nonhuman Primate CoreU54AI057156 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WALKER, DAVID H · 2003 to 2013
$102.6M
X-ray Crystallographic Studies on CalicivirusesP01AI057788 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB · 2004 to 2024
$34.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FASIHA KANWAL · 2001 to 2026
$28.3M
Host Genetic Susceptibility and Immune Responses to Norovirus InfectionsK23DK084513 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI KOO, HOONMO LEE · 2009 to 2012
$699k
NIAID NIH HHS P01 AI057788NIAID NIH HHS P01-AI-057788NIAID NIH HHS U54 AI057156NIAID NIH HHS U54-AI-057156NIDDK NIH HHS 1K23DK084513-01NIDDK NIH HHS K23 DK084513NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30-DK-56338
6 · The paper itself

Abstract

Noroviruses are the leading cause of foodborne disease outbreaks worldwide, and may soon eclipse rotaviruses as the most common cause of severe pediatric gastroenteritis, as the use of rotavirus vaccines becomes more widespread. Genetic mutations and recombinations contribute to the broad heterogeneity of noroviruses and the emergence of new epidemic strains. Although typically a self-limited disease, norovirus gastroenteritis can cause significant morbidity and mortality among children, the elderly, and the immunocompromised. The lack of a cell culture or small animal model has hindered norovirus research and the development of novel therapeutic and preventative interventions. However, vaccines based on norovirus capsid protein virus-like particles are promising and may one day become widely available through transgenic expression in plants.

Indexed as

GastroenteritisGenetic Predisposition to DiseaseGenetic VariationHumansInfection ControlNorovirus

Identifiers

PMID20670600
PMCPMC3150746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.