Trial reportBMC musculoskeletal disorders2010
Association between expression of the bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome.
Trial report in BMC musculoskeletal disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Synovial cytokine expression in ankle osteoarthritis depends on age and stage.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Trial
- Association between intraarticular cytokine levels and clinical parameters of osteochondritis dissecans in the ankle.BMC musculoskeletal disorders · 2014Trial
- Biochemical characterization of early osteoarthritis in the ankle.TheScientificWorldJournal · 2014Trial
- High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis.Diagnostics (Basel, Switzerland) · 2020Article
- Temporal TGF-β Supergene Family Signalling Cues Modulating Tissue Morphogenesis: Chondrogenesis within a Muscle Tissue Model?International journal of molecular sciences · 2020Article
- Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Correlation of synovial cytokine expression with quality of cells used for autologous chondrocyte implantation in human knees.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2014Article
- Regeneration of articular cartilage of the knee.Rheumatology international · 2013Review
- Autologous chondrocyte implantation in children and adolescents.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
- Genetic engineering of juvenile human chondrocytes improves scaffold-free mosaic neocartilage grafts.Clinical orthopaedics and related research · 2013Article
- Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions.TheScientificWorldJournal · 2012Article
- Advanced Therapy Medicinal Products and Exemptions to the Regulation 1394/2007: How Confident Can We be? An Exploratory Analysis.Frontiers in pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough there is much known about the role of BMPs in cartilage metabolism reliable data about the in vivo regulation in natural and surgically induced cartilage repair are still missing.
methodsLavage fluids of knee joints of 47 patients were collected during surgical therapy. 5 patients had no cartilage lesion and served as a control group, the other 42 patients with circumscribed cartilage defects were treated by microfracturing (19) or by an Autologous Chondrocyte Implantation (23). The concentrations of BMP-2 and BMP-7 were determined by ELISA. The clinical status was evaluated using the IKDC Score prior to and 1 year following the operation.
resultsHigh level expression in the control group was found for BMP-2, concentrations of BMP-7 remained below detection levels. No statistical differences could be detected in concentrations of BMP-2 or BMP-7 in the lavage fluids of knees with cartilage lesions compared to the control group. Levels of BMP-7 did not change after surgical cartilage repair, whereas concentrations of BMP-2 statistically significant increased after the intervention (p < 0.001). The clinical outcome following cartilage regenerating surgery increased after 1 year by 29% (p < 0.001). The difference of the IKDC score after 1 year and prior to the operation was used to quantify the degree of improvement following surgery. This difference statistically significant correlated with initial BMP-2 (R = 0.554, p < 0.001) but not BMP-7 (R = 0.031, n.s.) levels in the knee joints.
conclusionsBMP-2 seems to play an important role in surgically induced cartilage repair; synovial expression correlates with the clinical outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.