ArticleJournal of the American Geriatrics Society2010
Neuroimaging in the clinical diagnosis of dementia: observations from a memory disorders clinic.
Article in Journal of the American Geriatrics Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Regional cerebral blood flow single photon emission computed tomography for detection of Frontotemporal dementia in people with suspected dementia.The Cochrane database of systematic reviews · 2015Pooled it
- Comparison of conventional and actuarial neuropsychological criteria for mild cognitive impairment in a clinical setting.Journal of clinical and experimental neuropsychology · 2021Article
- Creation of an anthropomorphic CT head phantom for verification of image segmentation.Medical physics · 2020Article
- Neuroimaging referral for dementia diagnosis: The specialist's perspective in Ireland.Alzheimer's & dementia (Amsterdam, Netherlands) · 2015Article
- What do temporal lobe epilepsy and progressive mild cognitive impairment have in common?Frontiers in systems neuroscience · 2014Review
- Neurosyphilis manifesting with rapidly progressive dementia: report of three cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Clinical applications of neuroimaging in patients with Alzheimer's disease: a review from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012.Alzheimer's research & therapy · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo determine how often neuroimaging confirms, clarifies, or contradicts initial diagnoses of late-life cognitive disorders.
designRetrospective case review.
settingOutpatient clinic specializing in memory disorders.
participantsOne hundred ninety-three consecutively referred cognitively impaired patients. MEASUREMENTS: Diagnoses using research criteria were developed for each patient at the first visit and ranged from cognitive impairment without dementia to dementias of single, complex, or indeterminate etiology. Structural (noncontrast magnetic resonance imaging) and perfusion (technetium-99m ethyl cysteine dimer single photon emission computed tomography) images were categorized together as normal, suggestive of specific diseases, or abnormal/not diagnostic.
resultsWhen a single neurodegenerative disease was suspected clinically (n=94), imaging confirmed the diagnosis in 50, contradicted the diagnosis in 32, and was abnormal/not diagnostic in 12. When more than one neurodegenerative etiology was clinically suspected (n=21), imaging assigned a single diagnosis in 13 and only cerebrovascular disease in one and was abnormal/not diagnostic in seven. In dementia not otherwise specified (NOS) (n=33), imaging suggested a specific etiology in 23 and was abnormal/not diagnostic in 10. Abnormal/not diagnostic images were more common in cognitive disorder NOS (n=25, 68%) than in other clinical groups (22%, chi-square=22.8 P<.001). Neuroimaging indicators of cerebrovascular disease were common (60% prevalence) but not predicted by the presence of vascular risk factors alone.
conclusionOverall, neuroimaging confirmed, clarified, or contradicted the initial clinical diagnosis in more than 80% of patients, whereas fewer than 20% had abnormal/not diagnostic patterns. Imaging suggested a complex dementia etiology in 21% of cases clinically thought to be caused by a single process, whereas 46% of complex clinical differential diagnoses appeared to reflect a single causal pattern. Further work is needed to determine whether refinement of clinical diagnoses using specialized neuroimaging improves clinical decision-making and patient outcomes.
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