Evidence map›Paper›PMID 20669927›Full record

ArticleJournal of medicinal chemistry2010

Medicinal chemistry as a conduit for the modulation of quorum sensing.

Colin A Lowery, Nicholas T Salzameda, Daisuke Sawada, Gunnar F Kaufmann, Kim D Janda

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Genomic Features of a Food-DerivedInternational journal of molecular sciences · 2020
    Article
  4. Article
  5. Seed Extract ofFrontiers in cellular and infection microbiology · 2018
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Quorum quenching mediated approaches for control of membrane biofouling.International journal of biological sciences · 2014
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Colin A LoweryDepartment of Chemistry and Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA.
Nicholas T Salzameda
Daisuke Sawada
Gunnar F Kaufmann
Kim D Janda

Funding

Chemical Strategies to Manipulate A1-2 Signaling in Bacterial PathogensR01AI077644 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2010 to 2014
$2.3M
Bacterial Quorum Sensing as Target for Anti-Infective ImmunotherapyR01AI080715 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ZHOU, BIN · 2009 to 2013
$2.3M
Biological Implications of Tetramic AcidR21AI079503 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2009 to 2010
$522k
Oral Biofilms and the Immune SystemR21DE018452 · NIDCR · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2008 to 2009
$521k
NIAID NIH HHS AI077644NIAID NIH HHS AI079503NIAID NIH HHS R01 AI077644NIAID NIH HHS R01 AI080715NIAID NIH HHS R21 AI079503NIDCR NIH HHS DE018452NIDCR NIH HHS R21 DE018452
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acyl-ButyrolactonesAnimalsAnti-Bacterial AgentsDrug DiscoveryGram-Negative BacteriaGram-Positive BacteriaHomoserineHumansLactonesMolecular StructurePentanesPeptides, CyclicQuorum SensingStructure-Activity Relationship4,5-dihydroxy-2,3-pentanedioneAcyl-ButyrolactonesAnti-Bacterial AgentsHomoserineLactonesN-octanoylhomoserine lactonePentanesPeptides, Cyclic

Identifiers

PMID20669927
PMCPMC2974035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.