ArticleChemistry (Weinheim an der Bergstrasse, Germany)2010
Kinetic isotope effects in asymmetric reactions.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Overcoming a Radical Polarity Mismatch in Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone- and Carbonyl-Containing SFAngewandte Chemie (International ed. in English) · 2024Article
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- Highly selective catalytic transfer hydrodeuteration of cyclic alkenes.Journal of labelled compounds & radiopharmaceuticals · 2023Article
- Preparation of Deuterium-Labeled Armodafinil by Hydrogen-Deuterium Exchange and Its Application in Quantitative Analysis by LC-MS.Metabolites · 2022Article
- Indium Tribromide-Catalysed Transfer-Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- London Dispersion Interactions Rather than Steric Hindrance Determine the Enantioselectivity of the Corey-Bakshi-Shibata Reduction.Angewandte Chemie (International ed. in English) · 2021Article
- Temperature-Dependent Kinetic Isotope Effects in R67 Dihydrofolate Reductase from Path-Integral Simulations.The journal of physical chemistry. B · 2021Article
- Silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes.RSC advances · 2020Article
- Control of chemoselectivity in asymmetric tandem reactions: Direct synthesis of chiral amines bearing nonadjacent stereocenters.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Enthalpy/entropy contributions to conformational KIEs: theoretical predictions and comparison with experiment.Molecules (Basel, Switzerland) · 2013Article
- Catalytic Asymmetric [4 + 2] Additions with Aliphatic Nitroalkenes.Chemical science · 2011Article
- From bifunctional to trifunctional (tricomponent nucleophile-transition metal-lewis acid) catalysis: the catalytic, enantioselective α-fluorination of acid chlorides.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Kinetic isotope effects are exquisitely sensitive probes of transition structure. As such, kinetic isotope effects offer a uniquely useful probe for the symmetry-breaking process that is inherent to stereoselective reactions. In this Concept article, we explore the role of steric and electronic effects in stereocontrol, and we relate these concepts to recent studies carried out in our laboratory. We also explore the way in which kinetic isotope effects serve as useful points of contact with computational models of transition structures. Finally, we discuss future opportunities for kinetic isotope effects to play a role in asymmetric catalyst development.
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