ArticleMycopathologia2011
Genes potentially relevant in the parasitic phase of the fungal pathogen Paracoccidioides brasiliensis.
Article in Mycopathologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Hybrid histidine kinases and antifungal warfare in thermal dimorphic fungi.Antimicrobial agents and chemotherapy · 2026Review
- Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections.Microorganisms · 2023Review
- Metabolic Peculiarities ofFrontiers in microbiology · 2019Article
- Alterations of protein expression in conditions of copper-deprivation for Paracoccidioides lutzii in the presence of extracellular matrix components.BMC microbiology · 2014Article
- Fungal alternative splicing is associated with multicellular complexity and virulence: a genome-wide multi-species study.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Article
- The paracoccidioides cell wall: past and present layers toward understanding interaction with the host.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracoccidioides brasiliensis, a fungal pathogen of humans, switches from a filamentous spore-forming mold in the soil to a pathogenic budding-yeast in the human host. Dimorphism is regulated mainly by the temperature of incubation. Representational difference analysis (RDA) was performed between yeast cells of isolate Pb01 and from isolate Pb4940, the last growing as mycelia at the host temperature. Transcripts exhibiting increased expression during development of the yeast parasitic phase comprised those involved mainly in response to stress, transcriptional regulation and nitrogen metabolism. In this way, the isolate Pb01 increased the expression of a variety of transcripts encoding cell rescue proteins such as the heat shock protein HSP30, alpha-trehalose-phosphate synthase and DDR48 stress protein, suggesting the relevance of the defense mechanism against oxidative/heat shock stress in the fungal yeast phase. Other differentially expressed genes between the two isolates included those coding for cell wall/membrane-related proteins, suggesting the relevance of the fungal surface and it's remodeling to the dimorphism. We provide a set of novel yeast preferentially expressed genes and demonstrate the effectiveness of RDA for studying P. brasiliensis dimorphism.
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Registered trials
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