ArticleInternational journal of colorectal disease2010
Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats.
Article in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats.Inflammopharmacology · 2025Article
- Effects of the anti-inflammatory drug budesonide on the gut microbiota and cytokine production of 13-lined ground squirrels during prehibernation fattening.Physiological genomics · 2024Article
- Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon.Pharmaceutics · 2022Article
- Functional Plasmon-Activated Water IncreasesInternational journal of molecular sciences · 2022Article
- Nanogels of Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Preparation, In Vitro Characteristics and Therapeutic Potential.Pharmaceutics · 2019Article
- Sodium selenite ameliorates both intestinal and extra-intestinal changes in acetic acid-induced colitis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Evaluation of central and peripheral effects of doxepin on acetic acid-induced colitis in rat and the involved mechanisms.EXCLI journal · 2017Article
- Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Inflammatory cells' role in acetic acid-induced colitis.Advanced biomedical research · 2014Article
- Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats.International scholarly research notices · 2014Article
- Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats.Research in pharmaceutical sciences · 2013Article
- Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid.Digestive diseases and sciences · 2012Article
- Validation and optimization of experimental colitis induction in rats using 2, 4, 6-trinitrobenzene sulfonic acid.Research in pharmaceutical sciences · 2012Article
- Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats.Research in pharmaceutical sciences · 2011Article
- Effect of venlafaxine on experimental colitis in normal and reserpinised depressed rats.Research in pharmaceutical sciencesArticle
- Anti-inflammatory effect of Pycnocycla spinosa extract and its component isoacetovanillone on acetic acid induced colitis in rats.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-inflammatory drugs with high potency and low systemic adverse effects, such as budesonide, are drugs of choice for the treatment of ulcerative colitis (UC). Budesonide controlled-release formulations are now being used to induce and maintain clinical remission of Crohn's disease. Budesonide-dextran conjugates were synthesized as novel prodrugs of budesonide for oral controlled delivery of the major part of the drug to the colon without needing to coat the pellets of the drug. The aim of this study was to evaluate the in vivo efficacy of this conjugate against acetic acid-induced colitis in rats. MATERIALS AND
methodsExperimental UC was induced by rectal instillation of 4% solution of acetic acid to rats. After induction of colitis, rats were treated with vehicle (dextran solution), mesalasine (120 mg/kg), budesonide suspension (300 microg/kg) and BSD-70 (equivalent to 300 microg/kg of budesonide), prednisolon (4 mg/kg), hydrocortisone acetate enema (20 mg/kg), and 5-ASA enema (Asacol) (400 mg/kg) for 5 days and then colon macroscopic and microscopic sections were examined for inflammatory response.
resultsVehicle-treated rats presented bloody diarrhoea and gross lesions. The effective formulations for attenuating the damage were BSD-70, oral prednisolon and hydrocortisone acetate enema. Rats treated with BSD-70 showed huge improvement in macroscopic and histological scores of colitis compared to the negative control group and mesalasine and budesonide suspension.
conclusionData indicated that budesonide-dextran conjugate is effective in improving signs of inflammation in experimental model of colitis through selective delivery of the drug to the inflamed area.
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