ArticleEuropean journal of clinical pharmacology2010
Psychiatric comorbidity in patients with epilepsy: a population-based study.
Article in European journal of clinical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
- Psychiatric comorbidities and treatment patterns in epilepsy: A retrospective review from a tertiary neuropsychiatric clinic.Indian journal of psychiatry · 2026Article
- Psychiatric implications of anti-seizure medications in epileptic population.BMC neurology · 2024Article
- Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics.Molecular psychiatry · 2023Article
- Psychological comorbidities in epilepsy: a cross-sectional survey among Ghanaian epilepsy patients.Ghana medical journal · 2021Article
- Article
- Economic Value of Adjunctive Brivaracetam Treatment Strategy for Focal Onset Seizures in Finland.Advances in therapy · 2020Article
- High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.Epilepsy & behavior : E&B · 2019Article
- Article
- Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-a pharmacoepidemiological study and clinical implications.European journal of clinical pharmacology · 2016Article
- Network science for the identification of novel therapeutic targets in epilepsy.F1000Research · 2016Review
- Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2).Epilepsy & behavior : E&B · 2013Review
- Psychiatric disorders after epilepsy diagnosis: a population-based retrospective cohort study.PloS one · 2013Article
- Article
- CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.PLoS genetics · 2012Article
- Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1,300,000 older people.European journal of clinical pharmacology · 2011Article
- Long-term consequences after exposure to antiepileptic drugs in utero.Therapeutic advances in drug safety · 2011Review
- Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience.Epilepsia · 2011Review
- Women with epilepsy: clinically relevant issues.Functional neurologyReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with epilepsy often suffer from concomitant psychiatric disorders. Treatment patterns and the extent of comorbidity are insufficiently investigated and appropriate methods are scarce. The purpose of the study was to estimate the prevalence of psychiatric comorbidity in patients with epilepsy and to investigate prescription patterns of drugs prescribed for psychiatric disorders in epilepsy.
methodsPrescription data from the Norwegian Prescription Database (NorPD) regarding the use of CNS-active drugs included anonymous data from almost 190,000 patients and 1.1-1.3 million prescriptions per year (2004-2007). Searches were based upon use of specific drugs, defined daily doses, number of patients, prescriptions, gender, and age. Reimbursement codes related to psychiatric diagnosis were used as indicators for clinical use.
resultsThe prevalence of psychiatric comorbidity in patients with epilepsy was estimated to be 32%. There were 56% women and 44% men participating in the study. Among patients using antidepressants two thirds were women, but no gender differences were seen with antipsychotic medication. Antidepressants and antipsychotics were used 3.4 (20.9%) and 5.8 (13.4%) times more frequently than in the general population, accounting for 7.88 and 1.99 defined daily doses (DDDs)/1,000 inhabitants/day/year respectively. Lamotrigine was the most commonly used antiepileptic drug (AED) in epilepsy, accounting for 33% of the use of AEDs (in total 5.65 DDDs/1,000 inhabitants/day/year). The use of benzodiazepines was 9.55 DDDs/1,000 inhabitants/day/year. The patients had complex pharmacotherapy with two to eight concomitant drugs.
conclusionThe present study gives an estimate of psychiatric comorbidity of 32% in patients with epilepsy in a nation-wide population. The pharmacotherapy in this patient population is complex. The results provide valuable data on prescription patterns that contribute to pharmacovigilance on a national scale.
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