ArticleFunctional & integrative genomics2010
Zebrafish complement factor H and its related genes: identification, evolution, and expression.
Article in Functional & integrative genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Complement System Inhibitory Drugs in a Zebrafish (International journal of molecular sciences · 2023Article
- Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance.Frontiers in immunology · 2023Review
- A synthetic protein as efficient multitarget regulator against complement over-activation.Communications biology · 2022Article
- Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.Cell reports · 2022Article
- The time-dependent variations of zebrafish intestine and gill after polyethylene microplastics exposure.Ecotoxicology (London, England) · 2021Article
- Integrins meet complement: The evolutionary tip of an iceberg orchestrating metabolism and immunity.British journal of pharmacology · 2021Review
- What Goes Wrong during Early Development of Artificially Reproduced European EelAnimals : an open access journal from MDPI · 2021Article
- Carvacrol, Thymol, and Garlic Essential Oil Promote Skin Innate Immunity in Gilthead Seabream (Frontiers in immunology · 2021Article
- Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish.Frontiers in immunology · 2020Article
- Factor H Family Proteins in Complement Evasion of Microorganisms.Frontiers in immunology · 2017Review
- The Murine Factor H-Related Protein FHR-B Promotes Complement Activation.Frontiers in immunology · 2017Article
- Transcriptional response to heat shock in liver of snow trout (Schizothorax richardsonii)--a vulnerable Himalayan Cyprinid fish.Functional & integrative genomics · 2016Article
- Article
- Regulator of complement activation (RCA) group 2 gene cluster in zebrafish: identification, expression, and evolution.Functional & integrative genomics · 2012Article
- Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.Cellular microbiology · 2012Article
- Viral diseases in zebrafish: what is known and unknown.ILAR journal · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system consists of a number of serum and membrane-bound proteins that play a crucial role in protecting the host organism against microbial infection. Complement factor H (CFH) regulates the alternative pathway of complement in plasma and mediates discrimination of cellular surfaces to alternative pathway activators and non-activators. Although complement system of zebrafish has been extensively studied, the information regarding CFH and its related genes in this important model species remains lacking. In this study, we report the molecular cloning and identification of CFH and complement factor H-like 1-4 (CFHL1-4) in Danio rerio. Sequence comparison and phylogenetic, syntenic, as well as genomic structure analyses demonstrated that the scaffold encompassing CFH and CFHLs region was conserved during evolution from bony fish to humans, and CFH and CFHL1-4 originated by intra-chromosome duplication on chromosome 22. Besides, quantitative real-time polymerase chain reaction revealed that both zebrafish CFH and CFHLs were predominantly expressed in the liver in a tissue-specific manner, and their expression was inducible by lipopolysaccharide, an inducer of immune responses, suggesting that they are possibly involved in acute phase responses. These are the first such data in bony fish, laying a foundation for further study of their physiological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.