ArticleCurrent genetics2010
[NSI (+)]: a novel non-Mendelian nonsense suppressor determinant in Saccharomyces cerevisiae.
Article in Current genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Yeast red pigment, protein aggregates, and amyloidoses: a review.Cell and tissue research · 2022Review
- Biochemical Principles in Prion-Based Inheritance.Epigenomes · 2022Review
- Review
- Protein assembly systems in natural and synthetic biology.BMC biology · 2020Review
- Three J-proteins impact Hsp104-mediated variant-specific prion elimination: a new critical role for a low-complexity domain.Current genetics · 2020Review
- RNA Sequencing Reveals Specific TranscriptomicSignatures Distinguishing Effects of the [Genes · 2019Article
- A brief overview of the Swi1 prion-[SWI+].FEMS yeast research · 2018Review
- Protein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification.International journal of molecular sciences · 2018Review
- Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination.Molecular microbiology · 2018Article
- Prions and the concept of polyprionic inheritance.Current genetics · 2017Review
- Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae.PLoS genetics · 2016Article
- Prions, amyloids, and RNA: Pieces of a puzzle.Prion · 2016Review
- Improving industrial yeast strains: exploiting natural and artificial diversity.FEMS microbiology reviews · 2014Review
- Rebels with a cause: molecular features and physiological consequences of yeast prions.FEMS yeast research · 2014Review
- Review
- Prions in yeast.Genetics · 2012Review
- [NSI+] determinant has a pleiotropic phenotypic manifestation that is modulated by SUP35, SUP45, and VTS1 genes.Current genetics · 2012Article
- A small, glutamine-free domain propagates the [SWI(+)] prion in budding yeast.Molecular and cellular biology · 2011Article
- A new colour assay for [URE3] prion in a genetic background used to score for the [PSI⁺] prion.Yeast (Chichester, England) · 2011Article
- Newly identified prions in budding yeast, and their possible functions.Seminars in cell & developmental biology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-Mendelian determinants that control heritable traits in yeast are subdivided into two major groups-one that includes DNA- or RNA-based elements and another that comprises protein-based factors that are analogous to mammalian prion. All yeast non-Mendelian determinants show dominant inheritance, and some of them demonstrate cytoplasmic infectivity. Only prions, however, harbor-specific features, such as high frequency of induction following overproduction of prion-encoding protein, loss of the protein's normal function, and reversible curability. Here, we describe a novel nonchromosomal determinant that, in addition to [PSI (+)] and [ISP (+)], is involved in epigenetic control of nonsense suppression. This determinant, which we have designated [NSI (+)], causes nonsense suppression in the strains bearing the N-terminal-deleted or -modified SUP35 gene, but has no manifestation in the strains with the intact copy of SUP35. [NSI (+)] shows dominant non-Mendelian inheritance, reversible curability and may be transmitted by cytoduction, albeit with low frequency. Similar to yeast prions, this determinant can be cured by deletion or mutational inactivation of Hsp104. We have shown that [NSI (+)] does not correspond to the already identified yeast prions. Based on the data obtained, we hypothesize that [NSI (+)] is a novel prion factor involved in epigenetic control of nonsense suppression.
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