ReviewClinics (Sao Paulo, Brazil)2010
Fructose and cardiometabolic disorders: the controversy will, and must, continue.
Review in Clinics (Sao Paulo, Brazil), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- NAFLD in normal weight individuals.Diabetology & metabolic syndrome · 2022Review
- Dietary fructose and its association with the metabolic syndrome in Lebanese healthy adults: a cross-sectional study.Diabetology & metabolic syndrome · 2022Article
- Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis.Cellular and molecular life sciences : CMLS · 2020Review
- Impact of Alpha-Lipoic Acid Chronic Discontinuous Treatment in Cardiometabolic Disorders and Oxidative Stress Induced by Fructose Intake in Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-LeprThe Journal of veterinary medical science · 2017Article
- Role of Fructose as a Potent Antiarrhythmic and Anti-infarct agent in Isolated Rat Heart.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Hepatic function and the cardiometabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Review
- Energy-containing beverages: reproductive hormones and ovarian function in the BioCycle Study.The American journal of clinical nutrition · 2013Article
- Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose intolerance in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study.Nutrition & metabolism · 2011Article
- Starches, sugars and obesity.Nutrients · 2011Review
- Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice fed a high-fat diet with fructose.Journal of biomedicine & biotechnology · 2011Article
- Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil.Clinics (Sao Paulo, Brazil) · 2011Article
- Simvastatin-induced cardiac autonomic control improvement in fructose-fed female rats.Clinics (Sao Paulo, Brazil) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit.Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.