ArticleClinics (Sao Paulo, Brazil)2010
Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle.
Article in Clinics (Sao Paulo, Brazil), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix.Annals of biomedical engineering · 2021Article
- Ovarian status modulates cardiovascular autonomic control and oxidative stress in target organs.Biology of sex differences · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the amount of glycosaminoglycans in the uterine cervix during each phase of the rat estrous cycle.
designBased on vaginal smears, forty female, regularly cycling rats were divided into four groups (n = 10 for each group): GI - proestrous, GII - estrous, GIII - metaestrous and GIV - diestrous. Animals were sacrificed at each phase of the cycle, and the cervix was immediately removed and submitted to biochemical extraction and determination of sulfated glycosaminoglycans and hyaluronic acid. The results were analyzed by ANOVA followed by the Bonferroni post-hoc test.
resultsThe uterine cervix had the highest amount of total sulfated glycosaminoglycans and dermatan sulfate during the estrous phase (8.90 +/- 0.55 mg/g of cetonic extract, p<0.001; and 8.86 +/- 0.57 mg/g of cetonic extract, p<0.001). In addition, there was more heparan sulfate at the cervix during the proestrous phase (0.185 +/- 0.03 mg/g of cetonic extract) than during any other phase (p<0.001). There were no significant changes in the concentration of hyaluronic acid in the uterine cervix during the estrous cycle.
conclusionOur data suggest that the amount of total sulfated glycosaminoglycans may be influenced by hormonal fluctuations related to the estrous cycle, with dermatan sulfate and heparan sulfate being the glycosaminoglycans most sensitive to hormonal change.
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