ArticlePloS one2010
Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Viral Microglia Reprogramming Clears Oligomeric Neurotoxic Debris.bioRxiv : the preprint server for biology · 2026Article
- Polio virotherapy provokes MDA5 signaling and CD4Microbiology and molecular biology reviews : MMBR · 2025Review
- Targeting PVR (CD155) and its receptors in anti-tumor therapy.Cellular & molecular immunology · 2019Review
- Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.Science translational medicine · 2017Article
- NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.RNA (New York, N.Y.) · 2017Article
- Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics.International journal of molecular sciences · 2017Review
- Article
- Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.Molecular and cellular biology · 2015Article
- The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.Molecular and cellular biology · 2015Article
- Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.Current opinion in virology · 2015Review
- Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus.Discovery medicine · 2015Review
- Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage.BioMed research international · 2015Article
- Oncolytic polio virotherapy of cancer.Cancer · 2014Review
- NF90 in posttranscriptional gene regulation and microRNA biogenesis.International journal of molecular sciences · 2013Review
- Co-regulated expression of alpha and beta mRNAs encoding HLA-DR surface heterodimers is mediated by the MHCII RNA operon.Nucleic acids research · 2013Article
- p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.Molecular and cellular biology · 2013Article
- NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold.Nucleic acids research · 2012Article
- Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.Journal of virology · 2012Article
- The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.Molecular and cellular biology · 2011Article
- Oncolytic poliovirus against malignant glioma.Future virology · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulatory functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding proteins with their targets is regulated through changing subcellular distribution, post-translational modification or association with other proteins. METHODOLOGY: We demonstrate that the dsRNA binding protein 76 (DRBP76), synonymous with nuclear factor 90, displays inherently distinct tissue type-specific subcellular distribution in the normal human central nervous system and in malignant brain tumors of glial origin. Altered subcellular localization and isoform distribution in malignant glioma indicate that tumor-specific changes in DRBP76-related gene products and their regulatory functions may contribute to the formation and/or maintenance of these tumors. To identify endogenous mRNA targets of DRBP76, we performed RNA-immunoprecipitation and genome-wide microarray analyses in HEK293 cells, and identified specific classes of transcripts encoding critical functions in cellular metabolism. SIGNIFICANCE: Our data suggest that physiologic DRBP76 expression, isoform distribution and subcellular localization are profoundly altered upon malignant transformation. Thus, the functional role of DRBP76 in co- or post-transcriptional gene regulation may contribute to the neoplastic phenotype.
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