ArticlePloS one2010
Experimental selection for Drosophila survival in extremely high O2 environments.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis.Developmental biology · 2023Article
- Multiple mechanisms drive genomic adaptation to extreme ONature communications · 2021Article
- Investigating Developmental and Epileptic Encephalopathy UsingInternational journal of molecular sciences · 2020Review
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in aBiology open · 2020Article
- Article
- Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.Scientific reports · 2019Article
- RNA-Sequencing ofG3 (Bethesda, Md.) · 2018Article
- Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits.BMC biology · 2015Article
- Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.Aging cell · 2015Article
- MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data.BMC bioinformatics · 2014Article
- Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.PloS one · 2013Article
- Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production?Antioxidants & redox signaling · 2012Review
- Genome-wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster.PloS one · 2012Article
- Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.PloS one · 2012Article
- Review
- Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster.The Journal of biological chemistry · 2011Article
- Article
- Using Kepler for Tool Integration in Microarray Analysis Workflows.Procedia computer scienceArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although oxidative stress is deleterious to mammals, the mechanisms underlying oxidant susceptibility or tolerance remain to be elucidated. In this study, through a long-term laboratory selection over many generations, we generated a Drosophila melanogaster strain that can live and reproduce in very high O(2) environments (90% O(2)), a lethal condition to naïve flies. We demonstrated that tolerance to hyperoxia was heritable in these flies and that these hyperoxia-selected flies exhibited phenotypic differences from naïve flies, such as a larger body size and increased weight by 20%. Gene expression profiling revealed that 227 genes were significantly altered in expression and two third of these genes were down-regulated. Using a mutant screen strategy, we studied the role of some altered genes (up- or down-regulated in the microarrays) by testing the survival of available corresponding P-element or UAS construct lines under hyperoxic conditions. We report that down-regulation of several candidate genes including Tropomyosin 1, Glycerol 3 phosphate dehydrogenase, CG33129, and UGP as well as up-regulation of Diptericin and Attacin conferred tolerance to severe hyperoxia. In conclusion, we identified several genes that were not only altered in hyperoxia-selected flies but we also prove that these play an important role in hyperoxia survival. Thus our study provides a molecular basis for understanding the mechanisms of hyperoxia tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.