ArticleThe American journal of clinical nutrition2010
Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes.The Cochrane database of systematic reviews · 2024Pooled it
- Calcium supplementation during pregnancy and long-term offspring outcome: a systematic literature review and meta-analysis.Annals of the New York Academy of Sciences · 2022Pooled it
- Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.The Cochrane database of systematic reviews · 2018Pooled it
- Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes.The Cochrane database of systematic reviews · 2015Pooled it
- Evidence of an overweight/obesity transition among school-aged children and youth in Sub-Saharan Africa: a systematic review.PloS one · 2014Pooled it
- Pooled it
- Effects of maternal calcium supplementation on offspring blood pressure and growth in childhood and adolescence in a population with a low-calcium intake: follow-up study of a randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Trial
- Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial.The Journal of nutrition · 2019Trial
- Trial
- Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2021Article
- Associations Between Maternal Nutrition in Pregnancy and Child Blood Pressure at 4-6 Years: A Prospective Study in a Community-Based Pregnancy Cohort.The Journal of nutrition · 2021Article
- Article
- A systematic review on the effects of maternal calcium supplementation on offspring's blood pressure.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Birth weight, malnutrition and kidney-associated outcomes--a global concern.Nature reviews. Nephrology · 2015Review
- The effect of supplementary calcium on blood pressure in healthy adult women aged 18-30 years in Tehran, Iran.Journal of education and health promotion · 2015Article
- Dietary mineral supplies in Africa.Physiologia plantarum · 2014Article
- Calcium revisited: part II calcium supplements and their effects.BoneKEy reports · 2014Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundEvidence suggests that increased maternal calcium intake during pregnancy may result in lower offspring blood pressure, prompting calls for more robust data in this field, particularly in settings of habitually low calcium intake.
objectiveThe objective was to investigate the effect of maternal calcium supplementation on blood pressure in offspring by recruiting children born after a randomized, double-blind, placebo-controlled trial of calcium supplementation during pregnancy.
designChildren (n = 389) from a rural area of The Gambia (mean age: 7.4 ± 1.2 y; range: 5-10 y), whose mothers received a calcium supplement (1500 mg Ca/d from 20 wk of gestation until delivery) or placebo, were followed up in West Africa. Blood pressure was assessed under standardized conditions with use of the Omron 705IT automated oscillometric device (Morton Medical Ltd, London, United Kingdom), and anthropometric and body composition (bioelectrical impedance) measurements were also made.
resultsThe analysis was restricted to 350 children born at term, which represented 64% of original trial births. There was no difference in systolic (adjusted mean difference: -0.04 mm Hg; 95% CI: -1.78, 1.69 mm Hg) or diastolic (adjusted mean difference: 0.25 mm Hg; 95% CI: -1.27, 1.77 mm Hg) blood pressure between children whose mothers had received calcium and those who received placebo. No interaction between childhood body mass index (in kg/m(2); mean: 14.0) and maternal calcium supplementation was observed in this study.
conclusionCalcium supplementation in the second half of pregnancy in Gambian women with very low habitual calcium intakes may not result in lower offspring blood pressure at 5-10 y of age.
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Registered trials
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