ArticleEndocrinology2010
Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Macronutrient Supplements in Preterm and Small-for-Gestational-Age Animals: A Systematic Review and Meta-analysis.Scientific reports · 2019Pooled it
- Postnatal growth in preterm infants and later health outcomes: a systematic review.Acta paediatrica (Oslo, Norway : 1992) · 2015Pooled it
- A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies.The Journal of biological chemistry · 2024Article
- Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life.Chemosphere · 2023Article
- The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology.Molecular metabolism · 2023Article
- Animal Foetal Models of Obesity and Diabetes - From Laboratory to Clinical Settings.Frontiers in endocrinology · 2022Review
- Hypothalamic GHR-SIRT1 Axis in Fasting.Cells · 2021Article
- The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.Frontiers in physiology · 2021Review
- Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice.Science translational medicine · 2020Article
- Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to a diet rich in high fat and branched-chain amino acids.American journal of physiology. Endocrinology and metabolism · 2019Article
- Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.Frontiers in endocrinology · 2019Review
- Lactational programming of glucose homeostasis: a window of opportunity.Reproduction (Cambridge, England) · 2018Review
- Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus.Diabetes · 2018Article
- Feeding circuit development and early-life influences on future feeding behaviour.Nature reviews. Neuroscience · 2018Review
- Offspring neuroimmune consequences of maternal malnutrition: Potential mechanism for behavioral impairments that underlie metabolic and neurodevelopmental disorders.Frontiers in neuroendocrinology · 2017Review
- 10 lessons learned by a misguided physician.Physiology & behavior · 2017Review
- Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.Molecular metabolism · 2017Article
- Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits.Molecular metabolism · 2016Article
- Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.Aging cell · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Because rearing rats in large litters (LLs) protects them from becoming obese, we postulated that LL rearing would protect rats selectively bred to develop diet-induced obesity (DIO) from becoming obese by overcoming their inborn central leptin resistance. Male and female DIO rats were raised in normal litters (NLs; 10 pups/dam) or LLs (16 pups/dam) and assessed for anatomical, biochemical, and functional aspects of leptin sensitivity at various ages when fed low-fat chow or a 31% fat high-energy (HE) diet. LL rearing reduced plasma leptin levels by postnatal day 2 (P2) and body weight gain by P8. At P16, LL DIO neonates had increased arcuate nucleus (ARC) binding of leptin to its extracellular receptors and at P28 an associated increase of their agouti-related peptide and alpha-MSH axonal projections to the paraventricular nucleus. Reduced body weight persisted and was associated with increased ARC leptin receptor binding and sensitivity to the anorectic effects of leptin, reduced adiposity, and enhanced insulin sensitivity in LL DIO rats fed chow until 10 wk of age. The enhanced ARC leptin receptor binding and reduced adiposity of LL DIO rats persisted after an additional 5 wk on the HE diet. Female LL DIO rats had similar reductions in weight gain on both chow and HE diet vs. normal litter DIO rats. We postulate that LL rearing enhances DIO leptin sensitivity by lowering plasma leptin levels and thereby increasing leptin receptor availability and that this both enhances the ARC-paraventricular nucleus pathway development and protects them from becoming obese.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.